3,5,7-Trihydroxy-2-Phenyl-4H-Chromen-4-One 3,5,7-三羟基-2-苯基-4H-苯并吡喃-4-酮

CAS 548-83-4 MFCD00006833

化学结构图

548-83-4
SMILES: O=c1c(O)c(-c2ccccc2)oc2cc(O)cc(O)c12

化学属性

Mol. FormulaC15H10O5
Mol. Weight270.24
Melting Point214-215°C
TSCANo
Density1.579
Boiling Point518.6°C at 760 mmHg

别名和识别编码

Chemical Name3,5,7-Trihydroxy-2-Phenyl-4H-Chromen-4-One
MDL NumberMFCD00006833
CAS Number548-83-4
Synonym 3,5,7-TRIHYDROXYFLAVONE 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one 3,5,7-Trihydroxyflavone 3,5,7-Trihydroxyflavone (Galangin) 3,5,7-trihydroxy-2-phenyl-4-benzopyrone 3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on 3,5,7-trihydroxy-2-phenyl-chromen-4-one 3,5,7-trihydroxy-flavon 3,5,7-三羟基-2-苯基-4H-1-苯并呋喃-4-酮 3,5,7-三羟基黄酮 3,5.7-三羟基黄酮 4H-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl- GALANGIN hplc Galangin {Chemicalbook} NORIZALPININ Norizalpinin galangin {} {} {Chemicalbook} Galengin 高良姜精 高良姜精, 高良姜黄素,3,5,7-三羟基黄酮 高良姜素
Beilstein Registry Number272179
EC Number208-960-4
Merck Number14,4339
PubChem Substance ID5281616
Chemical Name Translation3,5,7-三羟基-2-苯基-4H-苯并吡喃-4-酮
Wiswesser Line NotationT66 BO EVJ CR& DQ GQ IQ
LabNetwork Molecule IDLN01305992
InChIInChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
Canonical SMILESO=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13
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分类

  • {SNA} Bioactive Small Molecules, Flavonoids, Flavonols, and Flavanols, G, Nutrition Research, Phytochemicals by Chemical Classification, 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, Flavonoids, Flavonols, and Flavanols, G, Phytochemicals by Chemical Classification, 生物活性小分子, 细胞生物学, 营养研究
  • {SNA} Bioactive Small Molecules, Cell Biology, Flavonoids, Flavonols, and Flavanols, G, Nutrition Research, Phytochemicals by Chemical Classification
  • {SNA} Flavonoids, Flavonols, and Flavanols, G, Phytochemicals by Chemical Classifi
  • {SNA} Flavonoids, Flavonols, and Flavanols, Phytochemicals by Chemical Classification, 细胞生物学,

产品应用

  • 能使鼠伤寒沙门氏菌ta98和ta100发生诱变。

相关文献及参考

  • [2]. Wen M, et al. Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 2012;89(5-6):247-55.
  • Merck:14,4339
  • Merck:14,4339 Beilstein: 18,V,4,567
  • [1]. Ciolino HP, et al. The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. Br J Cancer. 1999 Mar;79(9-10):1340-6.
  • [1]. Ciolino HP, et al. The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. Br J Cancer. 1999 Mar;79(9-10):1340-6.
  • [2]. Wen M, et al. Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 2012;89(5-6):247-55.

安全信息

RTECSLK9275500
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R000936/37/38
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DARUEE Dokl Akad Nauk resp. Uzb.  Volume(issue)/page/year: (9-10),55,1995

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 33 mg/kg
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 2,231,1980

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,45,1983

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 124,255,1983

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,45,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 65 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,45,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 133 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 54,297,197

Storage condition 2-8°C

其他信息

  • 高良姜素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L14223 3，5，7-三羟基黄酮, 97% 3,5,7-Trihydroxyflavone, 97% 25mg 911元 2010/05/25 L14223 3，5，7-三羟基黄酮, 97% 3,5,7-Trihydroxyflavone, 97% 100mg 2534元
  • MOL 文件:548-83-4.mol
  • Alfa Aesar:3，5，7-三羟基黄酮,97% 3,5,7-Trihydroxyflavone, 97%(548-83-4)
  • Sigma Aldrich:548-83-4(sigmaaldrich)
  • 用途一:能使鼠伤寒沙门氏菌ta98和ta100发生诱变。
  • F:10
  • 外观性质:微黄色针状结晶(乙醇), 尚易溶于乙醇及乙醚。在碱的水溶液中成黄色溶液。可升华。熔点：214-215℃
  • 尚易溶于乙醇及乙醚。在碱的水溶液中成黄色溶液。可升华。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. G - Bioactive Small Molecules
  1. Medical Research Areas
  2. Metabolism
  3. Cytochrome P450  (细胞色素P450)

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