Laudanosine 劳丹素(半日花素)

CAS 1699-51-0 MFCD00006910

化学结构图

1699-51-0
SMILES: COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2C)cc1OC

化学属性

Mol. FormulaC21H27NO4
Mol. Weight357

别名和识别编码

Chemical NameDL-LAUDANOSINE(WXG01661)
Wiswesser Line NotationT66 CNT&J B1R CO1 DO1& C1 HO1 IO1
Synonym (+-)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline (+-)-Laudanosine
CAS Number1699-51-0
InChIKeyKGPAYJZAMGEDIQ-UHFFFAOYSA-N
LabNetwork Molecule IDLN01821325
Chemical Name Translation劳丹素(半日花素)
PubChem Substance ID15548
InChIInChI=1S/C21H27NO4/c1-22-9-8-15-12-20(25-4)21(26-5)13-16(15)17(22)10-14-6-7-18(23-2)19(11-14)24-3/h6-7,11-13,17H,8-10H2,1-5H3
MDL Number
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相关文献及参考

  • [2]. D J Chapple, et al. Cardiovascular and Neurological Effects of Laudanosine. Studies in Mice and Rats, and in Conscious and Anaesthetized Dogs. Br J Anaesth. 1987 Feb;59(2):218-25.
  • [1]. V Fodale, et al. Laudanosine, an Atracurium and Cisatracurium Metabolite. Eur J Anaesthesiol. 2002 Jul;19(7):466-73.
  • [1]. V Fodale, et al. Laudanosine, an Atracurium and Cisatracurium Metabolite. Eur J Anaesthesiol. 2002 Jul;19(7):466-73.
  • [2]. D J Chapple, et al. Cardiovascular and Neurological Effects of Laudanosine. Studies in Mice and Rats, and in Conscious and Anaesthetized Dogs. Br J Anaesth. 1987 Feb;59(2):218-25.

安全信息

RTECSNX5070000
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 20,894,1977

系列性分类


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