Chymostatin -
CAS 9076-44-2 MFCD00071059
化学结构图
SMILES: CC(C)CC(NC(=O)C(NC(=O)NC(Cc1ccccc1)C(=O)O)C1CCN=C(N)N1)C(=O)NC(C=O)Cc1ccccc1
化学属性
| Mol. Weight | |
|---|---|
| Mol. Formula | CₓHyN₇O₆ |
| Density | 1.34 |
| Melting Point | 210-213ºC |
| Boiling Point | |
| Flash Point | - |
别名和识别编码
| Synonym | (2S)-2-[[(1S)-1-(2-Amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid Chymostatin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {A {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
|---|---|
| MDL Number | - |
| CAS Number | 9076-44-2 |
| Chemical Name | Chymostatin |
| Chemical Name Translation | - |
| InChIKey | QJIJPLFVFWXMGK-KSPFWWQASA-N |
| PubChem Substance ID | 443119 |
| InChI | InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1 |
| Canonical SMILES | - |
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分类
- {SNA} A to C, Apoptosis Enzymes, Application Index, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Cathepsin B, Cathepsin B Inhibitors, Cathepsin D, Cathepsin D Inhibitors, Cathepsin G, Cathepsin G Inhibitors, Cathepsin/Granzyme Inhibitors & Substrates, Cell Signaling Enzymes, Chymotrypsin, α-, Chymotrypsin, alpha-, Core Bioreagents, Cysteine Protease Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Individual Protease Inhibitors, Inhibitors, Life Science Reagents for Protein Expression and Purification, Lysosomal Proteases, P to Q, Papain,
相关文献及参考
- Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach New York, NY , (1989), 207,243
- Levy, M.R. and Chou, S.C. Biochim. Biophys. Acta 334 , 423, (1974)
- Umezawa, H Meth. Enzymol. 45 , 678, (1976) 摘要
- Feinstein, G., et al. Biochim. Biophys. Acta 429 , 925, (1976) 摘要
- Chang, K., et al., Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay Virology 423 , 125-33, (2012)
- Yoshida, T., et al., Comparative analysis of binding energy of chymostatin with human cathepsin A and its homologous proteins by molecular orbital calculation J. Chem. Inf. Model. 46 , 2093-103, (2012)
- Wang, S., et al., Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera J. Biosci. Bioeng. 113(1) , 42-7, (2011)
安全信息
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 23,425,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 6,57,1976
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