Benzenesulfonamide,N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-

CAS 1492-02-0 MFCD00724711

化学结构图

1492-02-0
SMILES: CC(C)(C)c1nnc(NS(=O)(=O)c2ccccc2)s1

化学属性

Mol. FormulaC12H15N3O2S2
Mol. Weight297.42

别名和识别编码

Chemical NameBenzenesulfonamide,N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
Wiswesser Line NotationT5NN DSJ CX1&1&1 EMSWR
Synonym 2-Benzenesulfonamido-5-tertiobutyl-1-thia-3,4-diazole 2-Benzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole Glybuzole N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide Desaglybuzole RP 7891 AN 1324 Gludiase TH-1395
Beilstein Registry Number1082473
CAS Number1492-02-0
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安全信息

RTECSDB1290000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 219 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 248 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,19

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1050 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969

系列性分类

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