Clindamycin Hydrochloride 盐酸克林霉素

CAS 21462-39-5 MFCD07793327

化学结构图

21462-39-5
SMILES: Cl.C[C@@H](Cl)[C@H](NC(=O)[C@H]1C[C@H](CCC)CN1C)[C@@H]1O[C@@H](SC)[C@@H](O)[C@H](O)[C@@H]1O |&1:2,4,8,10,17,19,22,24,26|

化学属性

Mol. FormulaC18
Mol. Weight461
Melting Point141 ºC
Appearance 白色结晶性粉末。极易溶于水，易溶于甲醇、吡啶，微溶于乙醇，几乎不溶于丙酮或氯仿，无臭，味苦。

别名和识别编码

Chemical NameClindamycin Hydrochloride
Synonym (7S)-7-Chloro-7-deoxylincomycin hydrochloride Cleocin 7-Chloro-7-deoxylincomycin hydrochloride Cleocin hydrochloride Clindamycin hydrochloride Clindimycin hydrochloride Clindomycin hydrochloride Dalacina U-21251F 盐酸克林霉素
MDL NumberMFCD07793327
Beilstein Registry Number4070786
EC Number244-398-6
PubChem Substance ID24892772
CAS Number21462-39-5
Chemical Name Translation盐酸克林霉素
Wiswesser Line NotationT6OTJ BS1 CQ DQ EQ FYYG1&MV- BT5NTJ A1 D3 &GH
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分类

  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, Chemical Structure Class, Core Bioreagents, Interferes with Protein Synthesis, Macrolides,
  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, Chemical Structure Class, Core Bioreagents, Interferes with Protein Synthesis, Macrolides, Mechanism of Action, Research Essentials, Spectrum of Activity, 抗生素, 生化试剂

安全信息

WGK Germany2
RTECSGF2275000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes Xi 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 361 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UPJOH* "Compounds Available for Fundamental Research, Volume II-6,
   Antibiotics, A Program of Upjohn Company Research Laboratory."  (Kalamazoo,
   MI 49001)  Volume(issue)/page/year: 2(6),-,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,516,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 273 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,331,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2193 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 18,354,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUT

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Spectrum of Activity - Antibiotics
  4. Antiparasitic / Antiprotozoal / Anthelminthic - Spectrum of Activity

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