2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(2-chlorophenyl)- Delorazepam

CAS 2894-67-9 MFCD00079156

化学结构图

2894-67-9
SMILES: O=C1CN=C(c2ccccc2Cl)c2cc(Cl)ccc2N1

化学属性

Mol. FormulaC15H10Cl2N2O
Mol. Weight305.17
Flash Point11 °C
Melting Point187-189°C

别名和识别编码

Chemical Name(100 ug/mL in Methanol)
CAS Number2894-67-9
Synonym Clordesmetildiazepam 1,3-Dihydro-7-chloro-5-(o-chlorophenyl)-2H-1,4-benzodiazepin-2-one 2-chloronordiazepam Chlordesmethyldiazepam 地洛西泮 delorazepam--deascheduleivitem EN 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro- Cl-DMDZ 2'-Chloronordiazepam 7-Chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one 5-(2-Chlorophenyl)-7-chloro-1,4-benzodiazepin-2-one 7-氯-5-(2-氯苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮 7-氯-5-(邻-氯苯基)-1,3-二氢-2H-1,4-苯并杂卓-2-酮 2-Chloronordiazepam NSC 169895 RV-12165 DELORAZEPAM B1, Benzodiazepine 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-chlorophenyl)- Chlordemethyldiazepam DELORAZEPAM 100 UG PER ML IN METHANOL ro5-3027 5-(2-chlorophenyl)-7-chloro-1,4-benzodiazepin-2-one RV 12165 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Delorazepam 7-氯-5-(2-氯苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮 7-CHLORO-5-[O-CHLOROPHENYL]-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE Ro 5- 1,3-dihydro-7-chloro-5-(2-chlorophenyl)-2h-4-benzodiazepin-2-one 7-CHLORO-5-(2-CHLORO-PHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE Ro 5-3027
MDL NumberMFCD00079156
PubChem Substance ID17925
EC Number200-659-6
Chemical Name TranslationDelorazepam
Wiswesser Line NotationT67 GMV JN IHJ CG KR BG
Beilstein Registry Number0754062
InChIInChI=1S/C15H10Cl2N2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
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分类

  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, D, DA - DH

产品应用

  • Controlled Substance.

安全信息

WGK Germany1
GHS Symbol
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
RTECSDF2367500
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P301+P310
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard Codes Xn,T,F
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Storage condition 2-8°C
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R22 Harmful if swallowed 吞咽有害
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
UN Number UN 1230 3/PG 2
Restrict {} 精神药品 精麻类化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 55860 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   125,31,1986

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 69890 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   125,31,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 28 ug/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - changes in motor activity (specific assay)
   Behavioral - antianxiety
REFERENCE :
   JCPCBR Journal of Clinical Pharmacology.  (Hall Assoc., PO Box 482,
   Stamford, CT 06904) V.13-    1973-  Volume(issue)/page/year: 16,481,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25050 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   125,31,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPEC

其他信息

  • MOL 文件:2894-67-9.mol
  • 用途一:用于合成劳拉西泮、三唑仑、氯马唑仑等原料药

系列性分类

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