4-Hydroxy-N’-((5-Nitrofuran-2-Yl)Methylene)Benzohydrazide 4-羟基-2’-(5-硝基呋喃甲叉)苯甲酰肼

CAS 965-52-6 MFCD00079482

化学结构图

965-52-6
SMILES: O=C(NN=Cc1ccc([N+](=O)[O-])o1)c1ccc(O)cc1

化学属性

Mol. FormulaC12H9N3O5
Mol. Weight275
Melting Point281-283 °C
SolubilitySoluble in water (practically insoluble), chloroform (practically insoluble), ethyl ether (0.01g/>100ml) (practically insoluble), Methanol (0.01g/100ml) (very slightly soluble), 1 N Sodium hydroxide (1.0g/30ml), and DMSO.

别名和识别编码

Chemical Name4-Hydroxy-N’-((5-Nitrofuran-2-Yl)Methylene)Benzohydrazide
CAS Number965-52-6
Synonym (5-Nitro-2-furfurylidene)(4-hydroxybenzoyl)hydrazine (Nitro-5' furfurylidene-2') hydroxy-4 benzhydrazide (nitro-5’furfurylidene-2’)hydroxy-4benzhydrazide 4-Hydroxybenzoic Acid 4-Hydroxybenzoic Acid 2-[(5-Nitro-2-furanyl)methylene]hydrazide 4-Hydroxybenzoic acid-[[5-nitro-2-furanyl] methylene] hydrazide 4-hydroxy-benzoicaci((5-nitro-2-furanyl)methylene)hydrazide 4-羟基-2'-(5-硝基呋喃甲叉)-苯酰肼 5-NITRO-2-FURALDEHYDE P-HYDROXYBENZOYLHYDRAZONE Adral Akabar BENZOIC ACID, 4-HYDROXY-, [(5-NITRO-2-FURANYL)METHYLENE]HYDRAZIDE Bacifurane Benzoic acid, 4-hydroxy-, ((5-nitro-2-furanyl)methylene)hydrazide Bifix Diarlidan Dicoferin Ediston Ercefurol Ercefuryl Eskapar NIFUROXA NIFUROXAZIDE
MDL NumberMFCD00079482
Beilstein Registry Number1352180
EC Number213-522-0
PubChem Substance ID5337997
Chemical Name Translation4-羟基-2’-(5-硝基呋喃甲叉)苯甲酰肼
Wiswesser Line NotationT5OJ BNW E1UNMVR DQ
LabNetwork Molecule IDLN00950132
InChIInChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
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分类

  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards N - O, Pharmaceutical Standards, Pharmacopeia Standards
  • Heterocycles
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, N, NA - NI, Others, 分析/色谱
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, N,
  • {SNA} Analy

产品应用

  • An inhibitor of STAT activation and signaling activity

相关文献及参考

  • Carron, M.C.E., et al.: Ann. Pharm. Fr., 21, 287 (1963),
  • Thabaut, A., et al.: Gaz. Med. Fr., 85, 4516 (1978),

安全信息

WGK Germany3
RTECSDH2528300
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 储存温度-20°C 储存温度 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,663,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 21,287,1963

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 250 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 187,55,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 157,1,1985

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P312
  • P304+P340
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • Sigma Aldrich:965-52-6(sigmaaldrich)
  • Nifuroxazide是可渗透细胞的，口服有效的硝基呋喃类止泻药，有效地抑制细胞内STAT1/3/5转录活性的激活，IC50为3 μM。
  • MOL 文件:965-52-6.mol
  • MSDS 信息:Nifuroxazide(965-52-6).msds

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. N - Alphabetic
  5. NA - NI - N
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Clinical Standards - Chromatography
  5. Antibiotics - Clinical Standards
  6. Chemical Structure - Antibiotics
  7. Others - Chemical Structure

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