TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 629 uL/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmingham, AL 35205) V.1-    1908-  Volume(issue)/page/year: 90,647,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 775 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1077,1995

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 300 ppm
REFERENCE :
   SHIGAZ Shigaku.  Ondotology.  (Nippon Shika Daigaku Shigakkai, 1-9-20
   Fujimi, Chiyodaku, Tokyo 102, Japan)  V.38-    1949-
   Volume(issue)/page/year: 74,1365,1987

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 10 ppm
REFERENCE :
   SHIGAZ Shigaku.  Ondotology.  (Nippon Shika Daigaku Shigakkai, 1-9-20
   Fujimi, Chiyodaku, Tokyo 102, Japan)  V.38-    1949-
   Volume(issue)/page/year: 74,1365,1987

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 10 ppm
REFERENCE :
   SHIGAZ Shigaku.  Ondotology.  (Nippon Shika Daigaku Shigakkai, 1-9-20
   Fujimi, Chiyodaku, Tokyo 102, Japan)  V.38-    1949-
   Volume(issue)/page/year: 74,1365,1987