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• {SNA} A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels
• A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels
• {SNA} A-AM, Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gat

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相关文献及参考

• Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010),
• Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),
• Ameri, A., The effects of Aconitum alkaloids on the central nervous system. Prog. Neurobiol. 56 , 211-235, (1998) 摘要
• Onur, R., et al., Effects of aconitine on neurotransmitter release in the rat neuromuscular junction. Neuropharmacology 34 , 1139-1145, (1995) 摘要
• Seitz, U., and Ameri, A, Different effects on [ 3 H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus. Biochem. Pharmacol. 55 , 883-888, (1998) 摘要
• Sawanobori, T., Effects of arrhythmic agents and Mg 2+ on aconitine-induced arrhythmias. Jpn. Heart J. 5 , 709, (1996)
• Ameri, A. and Simmet, T, Antagonism of the aconitine-induced inexcitability by the structurally related aconitum alkaloids, lappaconitine and ajacine. Brain Res. 842 , 332-341, (1999) 摘要
• Zhang, H.F. and Shi, Y.P., Preparation of Fe 3 O 4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples Anal. Chim. Acta 724 , 54-60, (2012)
• Li, N., et al., Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model Planta Med. 78(7) , 692-7, (2012)
• Liu, Y., et al., Study on the aconitine-type alkaloids of Radix Aconiti Lateralis and its processed products using HPLC-ESI-MS(n). Drug Test. Anal. , doi: 10.1002/dta.416., (2012)
• Merck 14 ,118
• Beil. 21 ,V,6,310

安全信息

GHS Symbol

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 350 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1291,1935

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 ug/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 26,221,1928

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(1),159,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
   2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan)  V.1-   1988-
   Volume(issue)/page/year: 2,225,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guin