1-(4-Methoxybenzyl)-3-(5-Nitrothiazol-2-Yl)Urea 1-(4-甲氧基苄基)-3-(5-硝基噻唑-2-基)脲
CAS 487021-52-3 MFCD08277040
化学结构图
SMILES: COC1C=CC(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)=CC=1
化学属性
| Mol. Formula | C12H12N4O4S |
|---|---|
| Mol. Weight | 308.31 |
别名和识别编码
| Chemical Name | 1-(4-Methoxybenzyl)-3-(5-Nitrothiazol-2-Yl)Urea |
|---|---|
| CAS Number | 487021-52-3 |
| Synonym | AR 0133418 AR-A014418 GSK 3B Inhibitor VIII N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea |
| MDL Number | MFCD08277040 |
| PubChem Substance ID | 329770820 |
| Chemical Name Translation | 1-(4-甲氧基苄基)-3-(5-硝基噻唑-2-基)脲 |
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分类
- Inhibitors
- Sulfur & Selenium Compounds,
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecule Alphabetical Index, Diversification
- Heterocycles
- Pharmaceuticals
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Glycobiology, Glycogen Synthase Kinase 3, Glycogen Synthase Kinase 3 (GSK3), Inhibitors, Inhibitors and Substrates, Kinase/Phosphatase Biology, Post-Translational Modification, Protein Kinase Inhibitors, Proteomics, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Serine/Threonine Phosphatase Inhibitors
- Intermediates & Fine Chemicals
- Aromatics
产品应用
- Glycogen Synthase Kinase 3? (GSK-3?) inhibitor.
相关文献及参考
- Koh, S., et al.:Toxicol., 247, 112 (2008),
- Vadivelan, S., et al.: Eur. J. Med. Chem., 44, 2361 (2009),
- Min, W., et al.: Neuropharmacol., 56, 463 (2009),
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护；
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H302 Harmful if swallowed 吞食有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
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