2H-1,2-Benzothiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide

CAS 34042-85-8 MFCD00866053

化学结构图

34042-85-8
SMILES: CN1C(=C(O)C2C=CC=CC=2S1(=O)=O)C(=O)NC1=NC=CS1

化学属性

Mol. FormulaC13H11N3O4S2
Mol. Weight337.39

别名和识别编码

Chemical Name2H-1,2-Benzothiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-thiazolyl-, 1,1-dioxide
CAS Number34042-85-8
Synonym CP 15973 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide
Beilstein Registry Number0628704
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Sudoxicam and Meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.

相关文献及参考

  • Wiseman, E., et al.: Biochem. Pharmacol., 21, 2323

安全信息

RTECSDL0710500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,848,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 136 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,1714,1978

系列性分类

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