Naftypramide

CAS 1505-95-9 MFCD00866058

化学结构图

1505-95-9
SMILES: CC(C)C(CCN(C)C)(C(N)=O)c1cccc2ccccc12

化学属性

Mol. FormulaC19H26N2O
Mol. Weight298.47

别名和识别编码

Chemical Name1-Naphthaleneacetamide,alpha-(2-(dimethylamino)ethyl)-alpha-isopropyl-
Wiswesser Line NotationL66J BXVZY1&1&2N1&1
Synonym DA 992 1-Naphthylacetamide, alpha-isopropyl-alpha-(2-dimethylaminoethyl)- Naftipramide Naphthipramide alpha-Isopropyl-alpha-(2-dimethylaminoethyl)-1-naphthylacetamide alpha-Isopropyl-alpha-(2-dimethylaminoethyl)-1-naphthacetamide Naftypramide alpha-Isopropyl-alpha-(2-(dimethylamino)ethyl)-1-naphthaleneacetamide Naphthypramide
Beilstein Registry Number2815141
CAS Number1505-95-9
PubChem Substance ID68954
InChIInChI=1S/C19H26N2O/c1-14(2)19(18(20)22,12-13-21(3)4)17-11-7-9-15-8-5-6-10-16(15)17/h5-11,14H,12-13H2,1-4H3,(H2,20,22)
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安全信息

RTECSQJ0700000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,594,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1030 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 16,720,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - nausea or vomiting
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,356,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year

系列性分类

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