5'-beta-H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 9-fluoro-11-beta,21-dihydroxy- 2'-methyl-,21-acetate
CAS 19888-56-3 MFCD00866081
化学结构图
SMILES: CC(=O)OCC(=O)[C@@]12N=C(C)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]21C
化学属性
| Mol. Formula | C25H30FNO6 |
|---|---|
| Mol. Weight | 459.56 |
别名和识别编码
| Chemical Name | 5'-beta-H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 9-fluoro-11-beta,21-dihydroxy- 2'-methyl-,21-acetate |
|---|---|
| CAS Number | 19888-56-3 |
| Synonym | Fluazacort Fluazacort acetato L 6400 Azacortid Fluazacort acetate (11?,16?)-21-(Acetyloxy)-9-fluoro-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione |
| Chemical Name Translation |
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分类
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Steroids
产品应用
- A glucucorticoid with anti-inflammatory properties used in the treatment of skin diseases.
相关文献及参考
- De Angelis, L.: Drugs Today, 12, 396 (1976); Nathansohn, G. et al.: Steroids, 13, 365 (1969); Lewis, J.D. et al.: Arzneim.-Forsch., 25, 1646 (1975);
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 12,396,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 54 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 12,396,1976
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