2-(5-benzoylthiophen-2-yl)propanoic acid 2-(5-苯甲酰基噻吩-2-基)丙酸

CAS 33005-95-7 MFCD00866089

化学结构图

33005-95-7
SMILES: CC(C(O)=O)C1=CC=C(S1)C(=O)C1C=CC=CC=1

化学属性

Mol. FormulaC14H12O3S
Mol. Weight260.31
Melting Point96.0 to 100.0 deg-C

别名和识别编码

Chemical Name2-(5-benzoylthiophen-2-yl)propanoic acid
CAS Number33005-95-7
Synonym (?)-Tiaprofenic Acid Tiaprofen ?-(5-Benzoyl-2-thienyl)propionic Acid Suralgan FC 3001 Tiaprofenic acid 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid Surgam RU 15060 5-Benzoyl-?-methyl-2-thiopheneacetic Acid (RS)-Tiaprofenic Acid
Wiswesser Line NotationT5SJ BY1&VQ EVR
Beilstein Registry Number1380662
Reaxys-RN1380662
Merck Number9422
Chemical Name Translation2-(5-苯甲酰基噻吩-2-基)丙酸
PubChem Substance ID253660472
MDL NumberMFCD00866089
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Tiaprofenic acid is a non-steroidal anti-inflammatory drug.

相关文献及参考

  • Clemence, F., et al.: Eur. J. Med. Chem., 9, 390 (1974),
  • Sorkin, E.M., et al.: Drugs, 29, 208 (1985),
  • Arrell, D., et al.: Clin. Pharmacol. Ther., 88, 120 (2010),

安全信息

RTECSXM7580000
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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,715,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 690 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,715,1975

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 168 mg/kg/14D-I
TOXIC EFFECTS :
   Vascular - shock
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 257 mg/kg/30D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1800 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
                          female 2 week(s) pre-mating  - 6 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   6,195,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   6,205,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 7200 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
                          female 2 week(s) pre-mating  - 6 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page

Hazard Class6.1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
GHS Symbol
UN Number 2811
Signal word
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII

系列性分类


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