2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide 2H-噻吩并[2,3-e]-1,2-噻嗪-3-羧酰胺,6-氯-4-羟基-2-甲基-N-2-吡啶基-,1,1-二氧化物
CAS 70374-39-9 MFCD00866163
化学结构图
SMILES: CN1C(=C(O)C2CC(Cl)=CC=2S1(=O)=O)C(=O)NC1=CC=CC=N1
化学属性
| Mol. Formula | C13H10ClN3O4S2 |
|---|---|
| Mol. Weight | 372 |
别名和识别编码
| Chemical Name | 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide |
|---|---|
| CAS Number | 70374-39-9 |
| Alfabeta Name | CHLOROHYDROXYMETHYLPYRIDINYLTHIENOTHIAZINECARBOXAMIDEDIOXIDE NHE642222312311[[]]---------------,,, |
| MDL Number | MFCD00866163 |
| Synonym | 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide Chlortenoxicam Ro 13-9297 TS 110 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide Chlortenoxicam CTX Chlortenoxicam Lornoxicam Ro 13-9297 TS 110 |
| Beilstein Registry Number | 1039965 |
| Chemical Name Translation | 2H-噻吩并[2,3-e]-1,2-噻嗪-3-羧酰胺,6-氯-4-羟基-2-甲基-N-2-吡啶基-,1,1-二氧化物 |
| PubChem Substance ID | 125308046 |
| Reaxys-RN | 1039965 |
| Merck Number | 5582 |
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分类
- {SNA} Arachidonic Acid Cascade, Cell Biology, Cell Signaling and Neuroscience, Cyclooxygenase, Enzyme Inhibitors, Lipids in Cell Signaling
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Cyclooxygenase, Enzyme Inhibitors, L, Lipids in Cell Signaling,
相关文献及参考
- [2]. Rose, P. and C. Steinhauser, Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig, 2004. 24(4): p. 227-36.
- [3]. Bianchi, M. and A.E. Panerai, Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res, 2002. 45(2): p. 101-5.
- [1]. Spyra S, et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174(16):2696-2705.
- [1]. Spyra S, et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174(16):2696-2705.
- [2]. Rose, P. and C. Steinhauser, Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig, 2004. 24(4): p. 227-36.
- [3]. Bianchi, M. and A.E. Panerai, Effects
安全信息
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310
- P301+P310+P330
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H300 Fatal if swallowed 吞食致命
- R28 Very toxic if swallowed 吞咽极毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5730 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,61,1989
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