7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone 普罗喹宗

CAS 22760-18-5 MFCD00866169

化学结构图

22760-18-5
SMILES: CC1C=CC2=C(C=1)N(C(C)C)C(=O)N=C2C1C=CC=CC=1

化学属性

Mol. FormulaC18H18N2O
Mol. Weight278.38

别名和识别编码

Chemical Name7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
Wiswesser Line NotationT66 BNVNJ BY1&1 ER& I1
Synonym SaH 43-715 Sandoz 43-715 Biarison Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl- RU 43715 Proquazone
CAS Number22760-18-5
Beilstein Registry Number0889725
Chemical Name Translation普罗喹宗
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安全信息

RTECSVA3530000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - antipsychotic
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 3,361,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 339 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,879,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 930 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 3,361,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 759 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somn

系列性分类

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