1-(2,4-Dichlorobenzyl)-1H-Indazole-3-Carboxylic Acid N-(2,4-二氯苯基)-1H-吲唑-3-羧酸
CAS 50264-69-2 MFCD00866285
化学结构图
SMILES: OC(=O)C1=NN(CC2=CC=C(Cl)C=C2Cl)C2C=CC=CC=21
化学属性
| Mol. Formula | C15H10Cl2N2O2 |
|---|---|
| Mol. Weight | 321 |
别名和识别编码
| Chemical Name | 1-(2,4-Dichlorobenzyl)-1H-Indazole-3-Carboxylic Acid |
|---|---|
| CAS Number | 50264-69-2 |
| Alfabeta Name | DICHLOROBENZYLINDAZOLECARBOXYLICACID H12413()------, |
| MDL Number | MFCD00866285 |
| Synonym | 1-(2,4-Dichlorbenzyl)-indazole-3-carboxylic acid 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid Diclondazolic acid 1H-Indazole-3-carboxylic acid, 1-((2,4-dichlorophenyl)methyl)- AF 1890 DICA Diclondazolic acid Doridamina Lonidamine |
| PubChem Substance ID | 24278515 |
| EC Number | 256-510-0 |
| Wiswesser Line Notation | T56 BNNJ B1R BG DG& DVQ |
| Beilstein Registry Number | 0894483 |
| Chemical Name Translation | N-(2,4-二氯苯基)-1H-吲唑-3-羧酸 |
| LabNetwork Molecule ID | LN00175707 |
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分类
- Aerobic Glycolysis (the Warburg Effect), Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Hexokinase (mitochondrial), cellular respiration, and glycolysis, Hexokinase Inhibitors, Inhibitors of Aerobic Glycolysis (the Warburg Effect), L, Mitochondrial Inhibitors, Nitric Oxide and Cell Stress
- {SNA} D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Hexokinase (mitochondrial), cellular respiration, and glycolysis, 一氧化氮和细胞应激,
相关文献及参考
- [2]. Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36.
- 1. Floridi, A., and Lehninger, A.L., Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria Arch. Biochem. Biophys. 226 , 73-83, (1983) 摘要
- Ben-Horin, H., et al. Cancer Res. 55 , 2814, (1995) 摘要
- Besner, J.G., et al. Drug Metab. Rev. 29 , 219, (1997) 摘要
- Merck 14 ,5568
- Pulselli, R., et al. Anticancer Res. 16 , 419, (1996) 摘要
- [1]. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57.
- [1]. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57.
- [2]. Nancolas B, et al. The anti-tumour agent lonidamine is
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P308+P313
- H351 Suspected of causing cancer 怀疑致癌
- H302 Harmful if swallowed 吞食有害
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R22 Harmful if swallowed 吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R60 May impair fertility 可能降低生殖能力
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 435 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 27(Suppl 2),91,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1700 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 27(Suppl 2),91,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 525 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) REFERENCE : CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 27(Suppl 2),91,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (spec
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 250 mg/kg/5D (Continuous) REFERENCE : EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 23,357,1975
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Oral TEST SYSTEM : Primate - monkey DOSE/DURATION : 250 mg/kg/5D REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 52,275,1978
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Leukocyte DOSE/DURATION : 10 umol/L REFERENCE : ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens 907, Greece) V.1- 1981- Volume(issue)/page/year: 6,749,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 35 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : PSSYDG Proceedings of the Serono Symposia. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1973- Volume(issue)/page/year: 14,453,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 90 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 5,197,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 175 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnor
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 100 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 2,353,1979
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