Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-

CAS 60784-46-5 MFCD00866383

化学结构图

60784-46-5
SMILES: OCCNC(=O)N(CCCl)N=O

化学属性

Mol. FormulaC5H10ClN3O3
Mol. Weight195.63

别名和识别编码

Chemical NameUrea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-
Synonym Elmustina 1-Nitroso-1-chloroethyl-3-hydroxyethylurea elmustine Hydroxyethyl CNU Hecnu 1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea Elmustine NSC-294895 CNU-ethanol Urea, N-(2-chloroethyl)-N'-(2-hydroxyethyl)-N-nitroso- 1-(2-Hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea
Wiswesser Line NotationQ2MVNNO&2G
Beilstein Registry Number1956525
CAS Number60784-46-5
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分类

  • {uni_hamburg} no charge; urea; alcohol; 1fragment

相关文献及参考

  • Short: III/35B Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts and Coupling Constants for Fluorine-19 and Nitrogen-15 Author: Balasubramanian, M.; Gupta, R.R.; Jain, M.; Perumal, S. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35B Year: 1998 ISBN: 3-540-63275-1 ISBN: 978-3-540-63275-7 Internet Resource: DOI:10.1007/b55685 RefComment: VII, 242 pages. With CD-ROM. Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonance data. Chemical shifts and coupling constants of boron-11 and phosphorus-31 (subvol. A), fluorine-19 and nitrogen-15 (subvol. B), hydrogen-1 (subvol. C), and carbon-13 (subvol. D) compounds are tabulated together with the gross- and structure formulas and the most readily available solvents. Due to the large amount of the data merely chemical shifts are presented in the printed versions, and all the data, chemical shifts and coupling constants are provided on CO-ROM's.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 96 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Gastrointestinal - tumors
REFERENCE :
   DTESD7 52 Vanderbilt Ave., New York, NY 10017)  V.1-15, 1977-87.
   Discontinued 52 Vanderbilt Ave., New York, NY 10017)  V.1-    1977-
   Volume(issue)/page/year: 8,273,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 64 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Gastrointestinal - tumors
REFERENCE :
   DTESD7 52 Vanderbilt Ave., New York, NY 10017)  V.1-15, 1977-87.
   Discontinued 52 Vanderbilt Ave., New York, NY 10017)  V.1-    1977-
   Volume(issue)/page/year: 8,273,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
   Gastrointestinal - tumors
REFERENCE :
   DTESD7 52 Vanderbilt Ave., New York, NY 10017)  V.1-15, 1977-87.
   Discontinued 52 Vanderbilt Ave., New York, NY 10017)  V.1-    1977-
   Volume(issue)/page/year: 8,273,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   DTESD7 52 Vanderbilt Ave., New York, NY 10017)  V.1-

RTECSYS4986000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25300 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Gastrointestinal - ulceration or bleeding from stomach
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 37,177,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,123,1981

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,514,1984

{h

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   DRISAA Drosophila Information Service.  (Cold Spring Harbor Laboratory, POB
   100, Cold Spring Harbor, NY 11724)  No.1-    1934- Volume(issue)/page/year:
   52,20,1977

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 178,157,1987

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 mmol/L/16H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,45,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lung
DOSE/DURATION           : 1 mg/L/1H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 44,87,1977

系列性分类

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