Acivicin 阿西维辛

CAS 42228-92-2 MFCD00058450

化学结构图

42228-92-2
SMILES: NC(C1CC(Cl)=NO1)C(O)=O

化学属性

Mol. FormulaC5H7ClN2O3
Mol. Weight178.59

别名和识别编码

Chemical NameAcivicin
CAS Number42228-92-2
Synonym (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid Antibiotic AT 125 α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic acid NSC 163501 U 42126 AT 125 Acivicine (a-S, 5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid NSC-163501 (?S,5S)-
MDL NumberMFCD00058450
Chemical Name Translation阿西维辛
Beilstein Registry Number1074648
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分类

  • Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Detection and Quantitation, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents, Reagents
  • {SNA} A - H, Amino Acids, Biochemicals and Reagents, Modified Amino Acids

产品应用

  • Azaserine and Acivicin are classical and irreversible inhibitors of ?-Glutamyltranspeptidase

相关文献及参考

  • Hanigan, M., et al.: Biochemistry, 32, 6302 (1993),
  • Vermeulin, M.A., et al., Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity. World J. Gastroenterol. 17 , 1569-1573, (2011)
  • Hilgier, W., et al., Direct exposure to ammonia and hyperammonemia increase the extracellular accumulation and degradation of astroglia-derived glutathione in the rat prefrontal cortex. Toxicol. Sci. 117 , 163-168, (2010)
  • Circu, M.L., et al., The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells. Biochem. Pharmacol. 77 , 76-85, (2009)

安全信息

WGK Germany3
RTECSNY2103000 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 223,129,1989

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 6 umol/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,633,1983

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Modified Amino Acids - Amino Acids
  5. A - H - Modified Amino Acids
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Multi-Drug Resistance - Multi-Drug Resistance and Drug Metabolism
  6. Detection and Quantitation - Multi-Drug Resistance
  7. Reagents - Detection and Quantitation
  1. imidoyl halide

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