Halopemide

CAS 59831-65-1 MFCD00866684

化学结构图

59831-65-1
SMILES: O=C1NC2C=C(Cl)C=CC=2N1C1CCN(CCNC(=O)C2C=CC(F)=CC=2)CC1

化学属性

Mol. FormulaC21H22ClFN4O2
Mol. Weight416.88

别名和识别编码

Chemical NameHalopemide
Synonym N-(2-(4-(5-Chloro-2-oxo-1-benzimidazolinyl)piperidino)ethyl)-p-fluorobenzamide
MDL NumberMFCD00866684
CAS Number59831-65-1
PubChem Substance ID329815189
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分类

  • Antagonists, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, Lipids in Cell Signaling, Neuroscience, Neurotransmission, Neurotransmitters, Phospholipase Inhibitors, Phospholipid Metabolism
  • {SNA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, Lipids in Cell Signaling, Neuroscience, Neurotransmission, Neurotransmitters, Phospholipase Inhibitors, Phospholipid Metabolism
  • {SNA} Antagonists, Bioactive Small Molecule Alphabetical Index, Dopaminergics, H, Lipids in Cell Signaling,

相关文献及参考

  • [2]. Neale R, et al. Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride. Psychopharmacology (Berl). 1981;75(3):254-7.
  • [3]. Skafi N, et al. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease. J Cell Physiol. 2019 Apr;234(4):4825-4839.
  • 1. Loonen, A.J., et al., Halopemide and benzodiazepine binding sites Arch. Int. Pharmacodyn. Ther. 258 , 1982, (51)
  • Monovich, L., et al, Optimization of Halopemide for Phospholipase D2 inhibition. Bioorg. Med. Chem. Lett. 17 , 2310-2311, (2007) 摘要
  • Scott, SA., et al, Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature Chem. Biol. 2 , 108-117, (2009) 摘要
  • Wenjuan, Su., et al, FIPI, a Phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol. Pharmacol. 2008 , 1, (2008) 摘要
  • {M

安全信息

GHS Symbol
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害

系列性分类


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