1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one 1-(4-氟苯基)-4-(4-(吡啶-2-基)哌嗪-1-基)丁-1-酮

CAS 1649-18-9 MFCD00866692

化学结构图

1649-18-9
SMILES: O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1

化学属性

Mol. FormulaC19H22FN3O
Mol. Weight327.44
Appearance 白色或类白色结晶粉末。熔点91-93℃。
SolubilityDMSO 65 mg/mL Water <1 mg/mL Ethanol 34 mg/mL
Melting Point87-89°C

别名和识别编码

Chemical Name1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one
CAS Number1649-18-9
Synonym 1-(4-FLUORO-PHENYL)-4-(4-PYRIDIN-2-YL-PIPERAZIN-1-YL)-BUTAN-1-ONE 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone, 4-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone, 4′-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone 1-(4-氟苯基)-4-[4-(2-吡啶基)-1-哌嗪]-1-丁酮 1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]- 4’-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone AZAPERON Azaperone Azeperone Butyrophenone, 4'-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]- Eucalmyl Fluoperidol Sedaperone vet Suicalm {} {} {Chemicalbo {} {} {haz 氟苯酮哌吡嗪
MDL NumberMFCD00866692
EC Number216-715-8
Chemical Name Translation1-(4-氟苯基)-4-(4-(吡啶-2-基)哌嗪-1-基)丁-1-酮
Wiswesser Line NotationT6N DNTJ D3VR DF& A- BT6NJ
Beilstein Registry Number0565491
LabNetwork Molecule IDLN00852123
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分类

  • {SNA} Additional Standards, All Doping Standards (A-Z), Analytical Standards, Antipsychotics Standards, Chromatography, Life Sciences Standards, Pharmaceuticals, Illicit Drugs & Alcohol, Pharmacology Standards, Steroids / Doping Agents Standards, Tranquilizer, 分析/色谱
  • {SNA} All Doping Standards (A-Z), Analytical Standards, Analytical/Chromatography, Chromatography, Doping Substances, Forensic and Veterinary Standards, Life Sciences Standards, Pharmacology Standards, Tranquilizer
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • Sedative; tranquilizer.

相关文献及参考

  • Heykants, et al.: Arzneim.-Forsch., 21, 982 (1971),

安全信息

RTECSEU4550000
GHS Symbol
Precautionary statements
  • P301+P310
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 6.1 Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Storage condition 0-6°C
UN Number 2811 UN2811 6.1/PG 3
Packing GroupIII
Safety Statements
  • S3/14 Keep in a cool place away from ... (incompatible materials to be indicated by the manufacturer) 保存在阴凉场所，远离（生产厂家指明的不兼容的物料）；
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1798,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 202 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1798,1974

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1798,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Wash

其他信息

  • 用途二:安定药。有机中间体。
  • MOL 文件:1649-18-9.mol
  • 用途一:用作有机合成中间体
  • Sigma Aldrich:1649-18-9(sigmaaldrich)
  • 阿扎哌隆
  • Azaperone 是一种吡啶哌嗪和丁酰苯类抗精神病药，具有镇静和止吐的效果，主要是在兽医上用作镇静剂

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Pharmacology Standards - Life Sciences Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Doping Substances - Forensic and Veterinary Standards
  6. All Doping Standards (A-Z) - Doping Substances
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Dopamine Receptor  (多巴胺受体)

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