Rifampicin S-Na Sodium 利福喷丁

CAS 61379-65-5 MFCD00866806

化学结构图

61379-65-5
SMILES: CO[C@H]1C=CO[C@@]2(C)OC3=C(C4=C(C(O)=C3C)C(O)=C(NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(/C=N/N1CCN(CC1)C1CCCC1)=C4O)C2=O |c:14,25,62,t:3,27|

化学属性

Mol. Weight877
Mol. FormulaC47H64N4O12

别名和识别编码

CAS Number61379-65-5
Chemical NameRifampicin S-Na Sodium
Synonym R 77-3 Rifapentin Antibiotic DL 473IT Priftin Cyclopentylrifampicin DL 473 R-773 Rifamycin AF/ACPP 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin Rifapentine MDL 473 Prifitin 3-[[(4-Cyclopentyl-1-piperazinyl)imino]methyl]rifamycin 3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV KTC 1
Chemical Name Translation利福喷丁
MDL NumberMFCD00866806
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分类

  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Semi-synthetic rifamycin. Antibacterial (tuberculostatic).

相关文献及参考

  • Arioli, V., et al.: J. Antibiot., 34, 1026 (1981),
  • Neu, H.C., et al.: Antimicrob. Agents Chemother., 24, 457 (1983),
  • Assandri, A., et al.: J. Antibiot., 37, 1066 (1984),

安全信息

RTECSJQ0902000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 27,242,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1026,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 27,242,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 710 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1026,1981

系列性分类

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