Adefovir 阿德福韦

CAS 106941-25-7 MFCD00866943

化学结构图

106941-25-7
SMILES: NC1=NC=NC2=C1N=CN2CCOCP(O)(O)=O

化学属性

Mol. FormulaC8H12N5O4P
Mol. Weight273

别名和识别编码

Chemical NameAdefovir
CAS Number106941-25-7
Alfabeta NameAMINOPURINYLETHOXYMETHYLPHOSPHONICACID H2699((()))-------
MDL NumberMFCD00866943
Synonym PMEA 9-(2-phosphonylmethoxyethyl)adenine ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid GS 0393 GS-393 GS 0393 GS-393 P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine PMEA
Chemical Name Translation阿德福韦
Beilstein Registry Number3561094
LabNetwork Molecule IDLN00176606
PubChem Substance ID329825251
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分类

  • {SNA} A-AM, AIDS and Viral Research Reagents, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation
  • Heterocycles
  • Pharmaceuticals
  • {SNA} A-AM, AIDS and Viral Research Reagents, Bioactive Small Molecule Alphabetical Index, Immune Cell Signaling and Blood, Immune System Regulation, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • Used as an antiviral.

相关文献及参考

  • Cundy, K.C., et al.: Antimicrob. Ag. Chemother., 39, 2401 (1995),
  • Naesens, L. et al.: Antiviral Chem. Chemother., 8, 1 (1997),
  • Kahn, J., et al.: J. Am. Med. Assoc., 282, 2305 (1999),

安全信息

Warnings IRRITANT
Safety Statements
GHS Symbol
Precautionary statements
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word
RTECSSZ6563500
Hazard Codes T
Risk Statements
UN Number
Packing GroupIII
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 40,1072,1996

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 40,1072,1996

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 100 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 311,305,1994

系列性分类


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