N-(2-(4-(3-(Isopropylamino)Pyridin-2-yl)Piperazine-1-Carbonyl)-1H-Indol-5-yl)Methanesulfonamide Methanesulfonate N-(2-(4-(3-(异丙基氨基)吡啶-2-基)哌嗪-1-羰基)-1H-吲哚-5-基)甲磺酰胺甲磺酸盐

CAS 147221-93-0 MFCD00866948

化学结构图

147221-93-0
SMILES: CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(NS(C)(=O)=O)ccc3[nH]2)CC1.CS(=O)(=O)O

化学属性

Mol. FormulaC22H28N6O3S · CH3SO3H
Mol. Weight552.67

别名和识别编码

Chemical NameN-(2-(4-(3-(Isopropylamino)Pyridin-2-yl)Piperazine-1-Carbonyl)-1H-Indol-5-yl)Methanesulfonamide Methanesulfonate
CAS Number147221-93-0
Synonym Delavirdine Delavirdine Mesylate Mesylate, Delavirdine N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide Methanesulfonate N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide mesylate N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide mesylate Rescriptor Rescriptor U 90152 U 90152S U-90152 U-90152S U90152 U90152S
MDL NumberMFCD00866948
PubChem Substance ID441386
Chemical Name TranslationN-(2-(4-(3-(异丙基氨基)吡啶-2-基)哌嗪-1-羰基)-1H-吲哚-5-基)甲磺酰胺甲磺酸盐
LabNetwork Molecule IDLN01267588
InChIInChI=1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)
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分类

  • Pharmaceuticals
  • {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, D-DIF, Diversification Ready Pharma-Developed Compounds, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Immune Cell Signaling and Blood, Immune System Regulation, Pfizer Compounds, R to Z, Reverse Transcriptase, AMV, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,

产品应用

  • A bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor.

相关文献及参考

  • Dueweke, T.J., et al.: Antimicrob. Ag. Chemother., 37, 1127 (1993),
  • McCance-Katz, E.F., et al., Drug interactions between opioids and antiretroviral medications: interaction between methadone, LAAM, and delavirdine. Am. J. Addict. 15 , 23-34, (2006)
  • Scott, L.J., and Perry, C.M., Delavirdine: a review of its use in HIV infection. Drugs 60 , 1411-1444, (2000)

安全信息

WGK Germany3
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P305+P351+P338
  • P308+P313
  • P337+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Immune Cell Signaling and Blood - Cell Signaling and Neuroscience
  5. Immune System Regulation - Immune Cell Signaling and Blood
  6. AIDS and Viral Research Reagents - Immune System Regulation
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Reverse Transcriptase, AMV - R to Z

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