5-(Aziridin-1-Yl)-2,4-Dinitrobenzamide 5-(氮丙啶-1-基)-2,4-二硝基苯甲酰胺
CAS 21919-05-1 MFCD00869490
化学结构图
SMILES: NC(=O)C1=CC(=C(C=C1[N+]([O-])=O)[N+]([O-])=O)N1CC1
化学属性
| Mol. Formula | C9H8N4O5 |
|---|---|
| Mol. Weight | 252.21 |
别名和识别编码
| Chemical Name | 5-(Aziridin-1-Yl)-2,4-Dinitrobenzamide |
|---|---|
| Synonym | 2,4-Dinitro-5-ethyleneiminobenzamide 5-(1-Aziridinyl)-2,4-dinitrobenzamide 5-(1-Aziridinyl)-2,4-dinitrobenzamide 5-(Aziridin-1-yl)-2,4-dinitrobenzamide 5-(1-Aziridinyl)-2,4-dinitrobenzamide; CB-1954 5-(Aziridin-1-yl)-2,4-dinitrobenzamide 5-Aziridino-2,4-dinitrobenzamide CB 1954 NSC 115829 |
| MDL Number | MFCD00869490 |
| PubChem Substance ID | 24278301 |
| CAS Number | 21919-05-1 |
| Beilstein Registry Number | 5825582 |
| Chemical Name Translation | 5-(氮丙啶-1-基)-2,4-二硝基苯甲酰胺 |
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分类
- {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, NAD(P)H quinone oxidoreductase 2,
- {SNA} Apoptosis and Cell Cycle, DNA Intercalators and Crosslinkers, DNA metabolism, Enzyme Substrates, NAD(P)H quinone oxidoreductase 2, Substrates by Enzyme, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents,
相关文献及参考
- Corbeaux, T., et al., Thymopoiesis In Mice Depends On A Foxn1-positive Thymic Epithelial Cell Lineage. Proc. Natl. Acad. Sci. U. S. A. 107 , 16613-8, (2010) 摘要
- Knox, R.J., et al., Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy. Cancer Res. 60 , 4179, (2000)
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraduodenal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Gastrointestinal - gastritis Gastrointestinal - ulceration or bleeding from stomach Blood - hemorrhage REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Gastrointestinal - gastritis Gastrointestinal - ulceration or bleeding from stomach Blood - hemorrhage REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,231,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Gastrointestinal - gastritis Gastrointestinal - ulceration or bleeding from stomach Blood - hemorrhage REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,231,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 176 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST : LD
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 ug/plate REFERENCE : MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,375,1987
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 5 ug/plate REFERENCE : MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,375,1987
TYPE OF TEST : DNA adduct TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 10 umol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 43,1249,1992
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 10 umol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 37,4661,1988
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 20 mg/L REFERENCE : MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,375,1987
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