Zofenopril calcium 佐芬普利钙
CAS 81938-43-4 MFCD08704648
化学结构图
SMILES: C[C@@H](CSC(=O)C1C=CC=CC=1)C(=O)N1C[C@@H](C[C@@H]1C(=O)O[Ca]OC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](C)CSC(=O)C1C=CC=CC=1)SC1C=CC=CC=1)SC1C=CC=CC=1 |&1:1,16,18,26,28,33|
化学属性
| Mol. Formula | C44H44CaN2O8S4 |
|---|---|
| Mol. Weight | 897 |
别名和识别编码
| Chemical Name | Zofenopril calcium |
|---|---|
| CAS Number | 81938-43-4 |
| Synonym | (4S)-1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline calcium salt Bifril-d5 Zofenil [1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl Ester Calcium Salt |
| MDL Number | MFCD00004046 |
| PubChem Substance ID | 329831603 |
| LabNetwork Molecule ID | LN01796031 |
| Chemical Name Translation | 佐芬普利钙 |
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信息真实价格透明
资金保障
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分类
- MTS & Sulfhydryl Active Reagents
- Pharmaceuticals
- {SNA} Angiotensin Metabolism, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bristol-Myers Squibb, Drug Efflux Pumps, Modulators for MRP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, Z, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Intermediates & Fine Chemicals,
- Inhibitors
产品应用
- Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.
相关文献及参考
- [2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6.
- [3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63.
- Gorren, A., et al.: Biochem. J., 331, 801
- [1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.
- [1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.
- [2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher
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