(7S,9S)-9-Acetyl-7-(((2R,4S,5S,6S)-4-Amino-5-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-Yl)Oxy)-6,9,11-Trihydroxy-7,8,9,10-Tetrahydrotetracene-5,12-Dione Hydrochloride (7S,9S)-9-乙酰基-7-((2R,4S,5S,6S)-4-氨基-5-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-6,9,11-三羟基-7,8,9,10-四氢并四苯-5,12-二酮盐酸盐

CAS 57852-57-0 MFCD00897212

化学结构图

57852-57-0
SMILES: Cl.CC(=O)[C@]1(O)CC2C([C@H](C1)O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1)=C(O)C1=C(C(=O)C3C=CC=CC=3C1=O)C=2O

化学属性

Mol. FormulaC26H27NO9.ClH
Mol. Weight534.00

别名和识别编码

Chemical Name(7S,9S)-9-Acetyl-7-(((2R,4S,5S,6S)-4-Amino-5-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-Yl)Oxy)-6,9,11-Trihydroxy-7,8,9,10-Tetrahydrotetracene-5,12-Dione Hydrochloride
CAS Number57852-57-0
Synonym 4-Demethoxydaunorubicin hydrochloride (7S,9S)-
Chemical Name Translation(7S,9S)-9-乙酰基-7-((2R,4S,5S,6S)-4-氨基-5-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-6,9,11-三羟基-7,8,9,10-四氢并四苯-5,12-二酮盐酸盐
Wiswesser Line NotationL E6 C666 BV MVT&&&J DQ FQ HV1 HQ KQ RQ
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分类

  • Drug Analogues
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Orally active anthracycline; analog of Daunorubicin. Antineoplastic.

相关文献及参考

  • Arcamone, F., et al.: Caner Treat. Rep., 60, 829 (1976),
  • Zini, G., et al.: Cancer Chemother. Pharmacol., 16, 107 (1986),
  • Gillies, H.C., et al.: Br.J. Clin. Pharmacol., 23, 303 (1987),

安全信息

RTECSHB7877000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5430 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,364,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4690 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,364,1995

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 60,829,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,364,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Or

系列性分类

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