(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE
CAS 150375-75-0 MFCD00922133
化学结构图
SMILES: COC1=CC(=CC=C1OC)S(=O)(=O)N1[C@@H](C(=O)N2CCC[C@H]2C(N)=O)[C@](O)(C2C=C(Cl)C=CC1=2)C1C=CC=CC=1Cl
化学属性
| Mol. Formula | C28H27Cl2N3O7S |
|---|---|
| Mol. Weight | 620.50 |
别名和识别编码
| Chemical Name | SR 49059 |
|---|---|
| Synonym | (2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-2-pyrrolidinecarboxamide (2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-2-pyrrolidinecarboxamide SR49059 SR49059 |
| MDL Number | MFCD00922133 |
| CAS Number | 150375-75-0 |
| Chemical Name Translation | |
| PubChem Substance ID | 329824460 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones, S, Sanofi Aventis, Vasopressin, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Approved Therapeutics/Drug Candidates,
相关文献及参考
- Decaux G., et al., Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet 9624th ed., 371 , 1624-1632, (2008)
- Bishara B., et al., Effects of novel vasopressin receptor antagonists on renal function and cardiac hypertrophy in rats with experimental congestive heart failure. J. Pharmacol. Exp. Ther. 2nd ed., 326 , 414-422, (2008) 摘要
- Serradeil-Le Gal, C., et al., Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors. J. Clin. Invest. 1st ed., 92 , 224-231, (1993) 摘要
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