Ritonavir 利托那韦

CAS 155213-67-5 MFCD00927142

化学结构图

155213-67-5
SMILES: CN(CC1=CSC(=N1)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1

化学属性

Mol. FormulaC37H48N6O5S2
Mol. Weight720.94
Melting Point120-122

别名和识别编码

Chemical NameRitonavir
CAS Number155213-67-5
Synonym A 84538 1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate Ritonavir A-84538 No Abbott 84538
MDL NumberMFCD00927142
Chemical Name Translation利托那韦
PubChem Substance ID329825441
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分类

  • Pharmaceuticals
  • {SNA} Bioactive Small Molecule Alphabetical Index, R, 生物活性小分子, 细胞生物学
  • Anti-virals
  • Non-nucleoside Reverse Transcriptase
  • Intermediates & Fine Chemicals
  • {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
  • Inhibitors,
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling,

产品应用

  • A selective HIV protease inhibitor.

相关文献及参考

  • [2]. Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277(1):423-31.
  • [3]. Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2(5):261-9.
  • [4]. Drewe J, et al. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem Pharmacol. 1999 May 15;57(10):1147-52.
  • [5]. Kumar GN, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug;27(8):902-8.
  • [6]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May

安全信息

Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
GHS Symbol
Precautionary statements
Hazard statements
  • H302+H312+H332
WGK Germany3
Signal word
RTECSXA5310000
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. New Products - Cell Signaling and Neuroscience
  5. Immune Cell Signaling - New Products
  1. Medical Research Areas
  2. Metabolism
  3. HIV Protease  (HIV蛋白酶)

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