Epirubicin Hydrochloride 盐酸表柔比星

CAS 56390-09-1 MFCD00941448

化学结构图

56390-09-1
SMILES: [2H]C([2H])([2H])OC1=CC=CC2=C1C(=O)C1=C(C2=O)C(O)=C2C[C@](O)(C[C@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C2=C1O)C(=O)CO

化学属性

Mol. Weight580.03
Mol. FormulaC27H29NO11.ClH

别名和识别编码

CAS Number56390-09-1
Chemical NameEpirubicin Hydrochloride
Synonym 4'-epi-Adriamycin hydrochloride Epirubicin hydrochloride 4'-Epidoxorubicin hydrochloride ########
Chemical Name Translation盐酸表柔比星
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Used as an antineoplastic.

相关文献及参考

  • Kolaric, K., et al.: J. Cancer Res. Clin. Oncol., 106, 148 (1983),
  • Arcamone, F., et al.: Cancer Chemother. Pharmacol., 12, 157 (1984),

安全信息

RTECSQI9295750 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,200,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,200,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,200,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,200,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Stu

系列性分类

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