20a-Hydroxypregn-4-en-3-one 20Α-羟基黄体酮

CAS 145-14-2 MFCD00009823

化学结构图

145-14-2
SMILES: CC(O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C

化学属性

Mol. FormulaC21H32O2
Mol. Weight316.48
Melting Point171-172 °C
Boiling Point451.7±14.0 °C at 760 mmHg

别名和识别编码

Chemical Name20a-Hydroxypregn-4-en-3-one
CAS Number145-14-2
Synonym 20α-Dihydroprogesterone {LY} 20α-Dihydroprogesterone {} {LY} 20α-Dihydroprogesterone {} {} {LY} 20α-Dihydroprogesterone {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 20α-Dihydroprogesterone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
MDL NumberMFCD00009823
EC Number205-649-5
Chemical Name Translation20Α-羟基黄体酮
Beilstein Registry Number2220567
LabNetwork Molecule IDLN00201630
PubChem Substance ID8956
InChIInChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1
Canonical SMILESC[C@H](O)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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分类

  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids

产品应用

  • ?4-Pregnen-20?-ol-3-one is the main metabolite of Progesterone (P755900). Studies shows regulation of estrogen receptor levels in breast cancer by ?4-Pregnen-20?-ol-3-one and other progesterone metabo

相关文献及参考

  • Zhang, L. et al.: Yaoz. Xueb., 39, 613 (2004); Pawlak, K.J. et al.: J. Steroid. Biochem. Mol. Biol., 107, 172 (2007);

安全信息

WGK Germany3
RTECSTU5559900
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 127,151,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 40 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 23,196,1972

Storage condition

系列性分类

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