2-(4-(2-(4-(1-(2-EthoxyEthyl)-1H-Benzo[d]Imidazol-2-yl)Piperidin-1-yl)Ethyl)Phenyl)-2-mEthylpropanoic Acid 2-(4-(2-(4-(1-(2-乙氧基乙基)-1H-苯并[d]咪唑-2-基)哌啶-1-基)乙基)苯基)-2-甲基丙酸

CAS 202189-78-4 MFCD09837814

化学结构图

202189-78-4
SMILES: CCOCCN1C(=NC2C=CC=CC1=2)C1CCN(CCC2C=CC(=CC=2)C(C)(C)C(O)=O)CC1

化学属性

Mol. FormulaC28H37N3O3
Mol. Weight463.62
Melting Point200.0 to 204.0 deg-C

别名和识别编码

Chemical Name2-(4-(2-(4-(1-(2-EthoxyEthyl)-1H-Benzo[d]Imidazol-2-yl)Piperidin-1-yl)Ethyl)Phenyl)-2-mEthylpropanoic Acid
CAS Number202189-78-4
Synonym 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-?,?-dimethylbenzeneacetic Acid
Chemical Name Translation2-(4-(2-(4-(1-(2-乙氧基乙基)-1H-苯并[d]咪唑-2-基)哌啶-1-基)乙基)苯基)-2-甲基丙酸
Reaxys-RN13851185
MDL NumberMFCD09837814
PubChem Substance ID354335500
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Bilastine is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.

相关文献及参考

  • [2]. Jauregizar, N., et al., Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine. Clin Pharmacokinet, 2009. 48(8): p. 543-54.
  • Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004),
  • Lehman, J., et al.: Drugs, 66, 2309 (2006),
  • Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000),
  • [1]. Corcostegui, R., et al., Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist: receptor selectivity and in vitro antihistaminic activity. Drugs R D, 2005. 6(6): p. 371-84.
  • [1]. Corcostegui, R., et al., Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist: receptor selectivity and in vitro antihistaminic activity. Drugs R D, 2005. 6(6): p. 371-84.
  • [2]. Jauregizar, N., et al., Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine. Clin Pharmacokinet, 2009. 48(8): p. 543-54.

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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