阿伐他汀钠盐 阿伐他汀钠盐
CAS 501121-34-2 MFCD09839951
化学结构图
SMILES: CC(C)C1=C(C(=C(C2C=CC(F)=CC=2)N1CC[C@H](O)C[C@H](O)CC(O)=O)C1C=CC=CC=1)C(=O)NC1C=CC=CC=1
化学属性
| Mol. Formula | C33H34FN2NaO5 |
|---|---|
| Mol. Weight | 580.62 |
别名和识别编码
| Chemical Name | (3S,5S)-Atorvastatin Sodium Salt |
|---|---|
| CAS Number | 501121-34-2 |
| Synonym | (?S,?S)-2-(4-Fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Sodium 3S,5S-Atorvastatin Sodium |
| Chemical Name Translation | 阿伐他汀钠盐 |
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分类
- Aromatics
- Chiral Reagents
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Pfizer compounds
产品应用
- A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolem
相关文献及参考
- [2]. Martina Korhonova, et al. Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes. PLoS One. 2015 Sep 14;10(9):e0137720.
- [3]. Elena G Shcherbakova , et al. High-Throughput Assay for Enantiomeric Excess Determination in 1,2- And 1,3-Diols and Direct Asymmetric Reaction Screening. Chemistry. 2017 Jul 26;23(42):10222-10229.
- Heinonen, T.M., et al.: Clin. Ther., 18. 853 (1996),
- Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993),
- [1]. Thomas A Kocarek, et al. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5.
- [1]. Thomas A Kocarek, et al. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5.
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