2-Chloropyridine 2-氯吡啶

CAS 109-09-1 MFCD00006228

化学结构图

109-09-1
SMILES: Clc1ccccn1

化学属性

Mol. FormulaC5H4ClN
Mol. Weight113.55
Density1.2
Refractive index1.5320
Flash Point65°(149°F)
TSCAYes
Boiling Point170°C
Melting Point-46°C
Vapor Pressure1.7 mmHg ( 20 °C)
Solubility溶于芳烃、卤代烃。

别名和识别编码

Chemical Name2-Chloropyridine
MDL NumberMFCD00006228
EC Number203-646-3
CAS Number109-09-1
Beilstein Registry Number105788
PubChem Substance ID7977
Synonym 2-Chloropyridine ,99% 萘脲 邻氯吡啶 α-chloropyridine 2-Pyridinyl chloride Pyridine, 2-chloro- alpha-Chloropyridine 2-CHLOROPYRIDINE 2-氯吡啶99﹪ o-Chloropyridine ALPHA-CHLOROPYRIDINE 2-氯吡啶 2CLPY 2-chloro-pyridin
Chemical Name Translation2-氯吡啶
Wiswesser Line NotationT6NJ BG
LabNetwork Molecule IDLN00198394
InChIInChI=1S/C5H4ClN/c6-5-3-1-2-4-7-5/h1-4H
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分类

  • {SNA} Building Blocks, C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines

产品应用

  • 医药、杀菌剂等,有机合成的中间体。

相关文献及参考

  • Reaction with the unimetal suberbase complex formed from 2 mol of n-BuLi and I mol of 2-(Dimethyl­amino)­ethanol, B23616, in hexane, gives products resulting from apparent metallation at the 6-position, providing useful access to 6-functionalized 2-chloropyridines: Org. Lett., 2, 803 (2000). See also 2-Methoxypyridine, A13675, for a similar effect.
  • Beilstein: 20,V,5,402

安全信息

RTECSUS5950000
Packing GroupII
UN Number UN2822 UN 2822 6.1/PG 2
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H301+H331
  • H310 Fatal in contact with skin 皮肤接触致命
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Signal word Danger
Hazard Codes T
Hazard Class6.1
Restrict 剧毒化学品
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - fatty liver degeneration
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    195

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 ppm/4H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - fatty liver degeneration
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1980 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 400 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 176,185,1987

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1920 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 4000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 163,23,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1920 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

其他信息

  • 2-氯吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 110015000 2-氯吡啶 2-Chloropyridine 99% 500 ML 973元 2010/06/21 110010025 2-氯吡啶 2-Chloropyridine 99% 2.5 LT 3865元 2010/06/21 110011000 2-氯吡啶 2-Chloropyridine 99% 100 ML 255元
  • 用途二:防霉剂如吡硫霉净的中间体。
  • 用途三:医药、杀菌剂等,有机合成的中间体。
  • Sigma Aldrich:109-09-1(sigmaaldrich)
  • Hazard Note:Toxic
  • 能随水蒸气挥发。溶解度: 27 g/l 水(20°C) ,>50 g/100ml 乙醇, 溶于醚。
  • 类别:有毒物品
  • MSDS 信息:2-氯吡啶(109-09-1).msds
  • 灭火剂:干粉, 泡沫, 砂土
  • 急性毒性:吸入-大鼠 LCL0: 100 PPM/4小时; 口服-小鼠 LD50: 110 毫克/公斤
  • 蒸气压:1.7 mm Hg ( 20 °C)
  • 上游原料:吡啶 --> 2-氨基吡啶
  • 用途一:用于医药、杀虫剂、有机合成
  • MOL 文件:109-09-1.mol
  • 储运特性:库房通风低温干燥; 与氧化剂, 食品分开储运
  • 下游产品:2-吗啉代吡啶-3-醛 --> 2-氯-3-吡啶甲醛 --> 二苯基-2-吡啶膦 --> 2-氯-4-硝基吡啶 N-氧化物 --> 4-吡啶-2-异恶唑-5-胺 --> 2-氯-6-三氟甲基烟酸 --> 氯吡脲 --> 5-氨基甲基-2-氯吡啶 --> N-(4-硝基吡啶-2-基)乙酰胺 --> 2-氨基-4-硝基吡啶 --> 2-乙酰氨基-4-硝基吡啶-N-氧化物 --> 2-氯吡啶-N-氧化物 --> 2-氨基-4-硝基吡啶-N-氧化物 --> 2-氯-4-氨基吡啶盐酸盐 --> 吡丙醚 --> 2-氯-4-硝基吡啶 --> 2-氯-3-(2-硝基苯甲酰氨基)吡啶 --> 双(1-羟基-1H-吡啶-2-硫代硫酸-O,S)铜
  • 可燃性危险特性:可燃; 燃烧产生有毒氧化氮, 氯化物气体
  • 检测方法:HPLC,NMR
  • 图谱信息:2-氯吡啶(109-09-1)红外图谱(IR1) 2-氯吡啶(109-09-1)核磁图( 13 CNMR) 2-氯吡啶(109-09-1)核磁图( 1 HNMR) 2-氯吡啶(109-09-1)质谱(MS)
  • Acros Organics:2-氯吡啶 2-Chloropyridine, 99%(109-09-1)
  • 毒性分级:高毒
  • Alfa Aesar:2-氯吡啶,99% 2-Chloropyridine, 99%(109-09-1)
  • 外观性质:无色液体。
  • 海关编码:29333999
  • 方法一:用2-氨基吡啶经桑德曼尔反应制得。

系列性分类


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