Bromoform 三溴甲烷

CAS 75-25-2 MFCD00000128

化学结构图

75-25-2
SMILES: BrC(Br)Br

化学属性

Mol. FormulaCHBr3
Mol. Weight253
Density2.89
Refractive index1.5950 to 1.5990
Vapor Density8.7 (vs air)
Boiling Point146-150
Vapor Pressure5 mmHg ( 20 °C)
Melting Point5-8
Flash PointNone
TSCAYes
Solubility略溶于水, 0.301 G/100 ML
Stability对光敏感

别名和识别编码

Chemical NameBromoform
Synonym CHBr3 CHBr3 (tribromo-methane) Formyltribromide Methane,tribromo- Methenyl tribromide Methyl tribromide NCI-C55130 Rcra waste number U225 Tribrommethaan Tribrommethan Tribromomethane bromoform methane, tribromo- methyltribromide tribromide tribromo-methan tribromomethane(bromoform) 三溴甲烷 三溴甲烷(溴仿) 125-01 [6] 溴仿 溴仿,三溴甲烷
CAS Number75-25-2
EC Number200-854-6
Beilstein Registry Number1731048
MDL NumberMFCD00000128
PubChem Substance ID5558
Merck Number1420
Reaxys-RN1731048
Chemical Name Translation三溴甲烷
Wiswesser Line NotationEYEE
LabNetwork Molecule IDLN00195512
InChIInChI=1S/CHBr3/c2-1(3)4/h1H
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分类

  • {SA} Alkyl, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, Organic Building Blocks
  • {SNA} A-B, Alpha Sort, Alphabetical Index
  • {SNA} A-B, Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Applications, B, BI - BZ, Bromo, Chemical Class, Chromatography, Disinfection Byproducts, Disinfection Product Residues and Solvents, Environmental Standards, Food & Beverage Analysis, Halogenated, Processing/Packaging Contaminants, Volatiles/ Semivolatiles, Waste water

产品应用

  • 测定分子量的溶剂,测定矿物的折射指数。按比重分离各种矿石。
  • 标准溶液用于水分析等以下用途。
  • 1、测定分子量的溶剂,测定矿物的折射指数。按比重分离各种矿石。
  • 2、工业上染料中间体、医药镇痛剂、空气熏蒸消毒剂、致冷剂、抗爆剂组分、树脂和石蜡的溶剂等。
  • 校准仪器和装置;评价方法;工作标准;质量保证/质量控制;其他。
  • 用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

相关文献及参考

  • For examples of the generation of dibromocarbene, using Potassium tert-butoxide, A13947, as base, see: Org. Synth. Coll., 6, 187 (1988); 7, 200 (1990). Alternatively, reactions can be carried out with aqueous OH- and a phase-transfer catalyst such as Benzyl­triethyl­ammonium chloride, A13268: Org. Synth. Coll., 8, 223 (1993), or using crown ether catalysis: Org. Synth., 75, 98 (1997).
  • Short: II/27B
  • Under phase-transfer conditions, allylic bromides undergo nucleophilic displacement by the tribromomethyl anion: J. Chem. Soc., Chem. Commun., 210 (1979).
  • Short: II/25B

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S63
Risk Statements
  • R11 Highly flammable 非常易燃
  • R22 Harmful if swallowed 吞咽有害
  • R23 Toxic by inhalation 吸入有毒
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R51/53
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P305+P351+P338
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H331 Toxic if inhaled 吸入中毒
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSPB5600000
Packing GroupIII
UN Number 2515
Storage condition 0-6°C 密封避光保存。 储存温度2-8℃ Light Sensitive 0-10°C 0-10
Hazard Codes 6.1 T,N T,N,F
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,2717,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10400 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-350,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1274 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 20(12),52,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1820 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,354,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 414 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 15,251,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals,"

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Non-mammalian species
DOSE/DURATION           : 5 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 292,83,1993

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 80 umol/L
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 32,72,1983

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 3000 ppm
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-350,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 666 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Leukocyte
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 300,241,1993

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TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 110 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,1,1985

其他信息

  • Acros Organics:三溴甲烷/溴仿 Bromofo
  • 爆炸物危险特性:与冠醚, 或KOH 反应爆炸
  • 毒性分级:中毒
  • 外观性质:
  • 储运特性:库房通风低温干燥; 与食品添加剂分开存放
  • 用途六:可用作染料中间体、消毒剂、镇痛剂、麻醉剂、制冷剂、选矿剂、沉淀剂、溶剂和抗爆液组分等。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。
  • MSDS 信息:三溴甲烷(75-25-2).msds
  • {Chemi
  • 图谱信息:三溴甲烷(75-25-2)红外图谱(IR1) 三溴甲烷(75-25-2)核磁图( 1 HNMR) 三溴甲烷(75-25-2)核磁图( 13 CNMR) 三溴甲烷(75-25-2)质谱(MS)
  • 职业标准:TWA
  • 敏感性:Light Sensitive
  • Alfa Aesa
  • 三溴甲烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 10022916 三溴甲烷;溴仿 100ml 115元 2011/08/23 10022926 三溴甲烷;溴仿 100ml 70元 2011/08/23 xp400265 三溴甲烷;溴仿 5ml 98元
  • 无色重质液体。有氯仿气味,味甜。能与醇、苯、氯仿醚、石油醚、丙酮和油类等任意混和,难溶于水。久贮逐渐分解成黄色液体,空气及光可加速其分解,可加入乙醇作稳定剂。
  • 用途四:1、测定分子量的溶剂,测定矿物的折射指数。按比重分离各种矿石。2、工业上染料中间体、医药镇痛剂、空气熏蒸消毒剂、致冷剂、抗爆剂组分、树脂和石蜡的溶剂等。校准仪器和装置;评价方法;工作标准;质量保证/质量控制;其他。
  • TCI Shanghai:溴仿(含稳定剂二苯胺) Bromoform (stabiliz
  • 挥发性有机化合物(VOCs)单组分标准液
  • 蒸气压:5 mm Hg ( 20 °C)
  • 方法一:由丙酮与次溴酸钠反应而得。先用溴素与碱液配制次溴酸钠,在碱性条件下,将丙酮迅速加入0-5℃的次溴酸钠中,使温度保持在30-50℃,待温度下降后,继续搅拌10min。丙酮与次溴酸钠反应经由三溴丙酮而分解为溴仿。静置分层,蒸馏,洗涤、过滤,干燥而得成品。原料消耗定额:丙酮650kg/t、溴素3500kg/t。
  • Acros O
  • 类别:有毒物质
  • Acros Or
  • 上游原料:氢氧化钠 --> 硫酸 --> 碳酸钠 --> 溴 --> 氢氧化钾 --> 丙酮 --> 盐酸羟胺 --> 硫代硫酸钠 --> 硫代硫酸钠 --> 溴丙酮 --> 亚溴酸钠 --> 次溴酸钠
  • 蒸气密度:8.7 (vs air)
  • 用途五:测定分子量的溶剂,测定矿物的折射指数。按比重分离各种矿石。
  • 用途一:用作消毒剂、镇痛剂、致冷剂、灭水剂、抗爆剂、溶剂等
  • 可燃性危险特性:不燃; 高热分解; 燃烧释放有毒溴化物烟雾
  • Sigma Aldrich:75-25-2(sigmaaldrich)
  • 下游产品:1R,3R-二溴菊酸 --> 二溴甲烷
  • 用途二:用作分析试剂及测定分子量时的溶剂
  • 用途三:可用作染料中间体、消毒剂、镇痛剂、麻醉剂、制冷剂、选矿剂、沉淀剂、溶剂和抗爆液组分等。
  • {Chemic
  • MOL 文件:75-25-2.mol
  • 急性毒性:口服-大鼠 LD50: 933 毫克/公斤; 口服-小鼠 LD50: 1072 毫克/公斤
  • 灭火剂:雾状水、泡沫、二氧化碳、砂土。

系列性分类