Sodium hydride 钠氢60%

CAS 7646-69-7 MFCD00003471

化学结构图

7646-69-7
SMILES: [NaH]

化学属性

Mol. FormulaNaH
Mol. Weight24
Density1.2
Melting Point800
TSCAYes
Solubility起反应
Flash Point185°C
Stability对湿度敏感
Appearance powder (moistened with oil)

别名和识别编码

Chemical NameSodium hydride
Synonym sodium (I) hydride {uni_hamburg} SODIUM HYDRIDE, 55-65% (GASVOLUMETRIC) 氢化钠(60%分散在矿物油中) Sodiumhydride,60%inoil Sodium hydride inoil gray powder Sodium hydride dispersionin mineral oil 氢化钠, 57-63% OIL DISPERSION 氢化钠 氢化钠,油液分散氢化钠 SODIUM HYDRIDE, 60% DISPERSION IN MINERA L OIL sodiummonohydride 硫氫化鈉 NaH 氫化鈉 SODIUM HYDRIDE (60% DISPERSION) sodiumhydride[nah] SODIUM HYDRIDE Sodium hydride, 60% dispersion in mineral oil, in resealable cans Sodium monohydride NAH 80 Sodiumhydride,57-63%oildispersion Sodium hydride (NaH) SODIUM HYDRIDE, DRY, 95% NATRIUMHYDRID 60 %IGE SUSPENSION IN OEL nah80 Natriumhydrid sodium hydride sodiumhydride(nah) SodiumHydrideSuspension(60%InParaffinOil) Sodium hydride, 60%disp. in oil. In toluene or DMF solub. Bags SODIUM HYDRIDE DISPERSION
CAS Number7646-69-7
EC Number231-587-3
Beilstein Registry Number2384789
MDL NumberMFCD00003471
PubChem Substance ID24758
Merck Number8625
Chemical Name Translation钠氢60%
LabNetwork Molecule IDLN00195368
InChIInChI=1S/Na.H/q+1;-1
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分类

  • {SNA} 12 Principles Aligned Products, Alternative Energy, Chemical Synthesis, Greener Alternative Products, Material Sciences, Materials for Hydrogen Storage, Metal Hydrides, Reduction, Synthetic Reagents, 材料科学
  • {SNA} Alternative Energy, Chemical Synthesis, Materials Science, Materials for Hydrogen Storage, Metal Hydrides, Reduction, Synthetic Reagents
  • {SNA} Alternative Energy, Chemical Synthesis, Enabling Products, Greener Alternative Products, Material Sciences, Materials for Hydrogen Storage, Metal Hydrides, Reduction,
  • {SNA} Alternative Energy,

产品应用

  • 在有机合成中用作还原剂、缩合剂、烷基化试剂、氢化催化剂、克莱逊氏试剂,用作释氢剂。

相关文献及参考

  • Short: II/24C
  • CAUTION! Many literature procedures employ NaH in DMF, and this system is often used routinely by research workers as a 'convenient' general purpose strong base. It should be noted, especially when considering scale-up of such reactions, that thermal runaways have been observed with NaH/ DMF, with self-heating beginning at temperatures as low as 26oC in some cases: Chem. Eng. News, 60(28), 5; 60(37), 5 (1982). A similar effect was also noted with N,N-dimethylacetamide. More recently also, incidents have been reported with other dipolar aprotic solvents 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) and Dimethyl sulfoxide (DMSO): Org. Process. Res. Dev., 7, 1030 (2003).
  • Short: II/24A
  • For a review of sodium hydride-based complex reducing agents, see: Acta Chem. Scand., 44, 274 (1990).
  • Merck: 14,8625
  • Widely used strong base for the irreversible formation of Na derivatives. If required, the protective oil can be removed by repeated washing and decantation with low-boiling petroleum, see, e.g.: Org. Synth. Coll., 6, 684 (1988), but for many purposes, this is not necessary, and the oil can be removed by incorporating a suitable extraction or washing step in the work-up. There are numerous Organic Syntheses references to reactions using NaH.
  • Used in the deprotonation of DMSO to form "dimsyl sodium", a useful strong base for e.g. the Wittig reaction: J. Org. Chem., 28, 1128 (1963).

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中,保持干燥;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R15 Contact with water liberates extremely flammable gases 遇水会释放出极端易燃的气体
  • R35 Causes severe burns 会导致严重灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. 远离任何与水接触的可能,因为会剧烈反应可能产生闪火。
  • P231+P232
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P370+P378
  • P402+P404
  • P422 Store contents under… 存储目录在…之下。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H228 Flammable solid 易燃固体
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H260 In contact with water releases flammable gases which may ignite spontaneously 与水接触时释放可燃气体,可自燃。
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing GroupI
UN Number 1427
Storage condition Store at RT. Air & Moisture Sensitive 充氩保存 铝罐包装密封
Hazard Codes 4.3 F F,C
RTECSWB3910000
Hazard Class4.3
Warnings 危化品目录(2015)

其他信息

  • Acros Organics:Sodium hydride, dispersion in mineral oil, 75%(7646-69-7)
  • {Chem
  • {
  • 氢化钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 C332141000 氢化钠 100g 460元 2011/08/23 C332145000 氢化钠 500g 1182元 2011/08/23 K7162002 氢化钠55-65%,purum 100g 485元
  • 储运特性:库房通风
  • 理化性质:氢化钠属于离子晶体,类盐化合物,其中氢为负一价离子。加热
  • MSDS 信息:7646-69-7.msds
  • 上游原料:甲醇 --> 钠 --> 氢
  • 可燃性危险特性:遇水、湿空气放出氢气可燃
  • Sigma Aldrich:7646-69-7(sigmaaldrich)
  • 下游产品:6-(1H-吡唑-1-基)烟酰腈 --> 2-四氢吡喃-4-乙醇 --> 环辛酮 --> 5-氯-2-甲基苯并噻唑 --> 替马沙星 --> 沙拉沙星 --> 菲宁达 --> 5-氟吲哚-2-酮 --> (6-(1H-吡唑-1-基)吡啶-3-基)甲醇 --> (R)-苄氧甲基环氧乙烷 --> 亚精胺 --> 3-氨基苯并呋喃-2-甲酸乙酯 --> 2-甲基嘧啶-4-醇 --> 3-氨基-2,2-二甲基-1-丙醇 --> 7-甲基-1,6-辛二烯 --> 硝酸舍他康唑 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 2,4-二苄氧基-5-溴嘧啶 --> 4-甲氧基乙酰乙酸乙酯 --> 3-氨基-呋喃并[2,3-B]嘧啶-2-甲酸乙酯 --> 2,2-二甲基环己酮 --> 1-苄基-2-甲基咪唑 --> 甲基柏木醚 --> 6-吡唑-1-基烟酸甲酯 --> 3,5-二氟苯乙酸 --> 2,4,6-三(2-吡啶基)三嗪 --> 氟司喹南 --> 氯康唑 --> 烟酰乙酸甲酯
  • 外观性质:白色至淡灰色的细微结晶,以25-50%比例分散在油中。
  • 以25%-50%比例分散在油中,氢化钠制成品是一个氢化钠在矿物油中的50~80的微晶分散体。典型粒度范围为5-50微米。在800°C熔化同时分解,不溶于液氨、苯、二硫化碳、四氯化碳、熔融的氢和其它有机溶剂;在室温下的干燥空气或氧气中稳定,在潮湿空气中极易水解;遇水剧烈反应。
  • TCI Shanghai:氢化钠(60%,分散于液状石蜡) Sodium Hydride (60%, dispersion in Paraffin Liquid)(7646-69-7)
  • 类别:遇水燃烧物品
  • Alfa Aesar:氢化钠,57-63%oildispersion Sodium hydride, 57-63% oil dispersion(7646-69-7)
  • 以25%-50%比例分散在油中,氢化钠制成品是一个氢化钠在矿物油中的50~80的微晶分散体。典型粒度范围为5-50微米。在800°C熔化同时分解,不溶于液氨、苯、二硫化碳、四氯化碳、熔融的氢和其它有机溶剂;在室温下的干燥
  • 敏感性:Air & Moisture Sensitive
  • 用途二:在有机合成中用作还原剂、缩合剂、烷基化试剂、氢化催化剂、克莱逊氏试剂,用作释氢剂。
  • 存储注意事项:湿度敏感;氮气保护
  • {Chemicalbook
  • 上游原料:甲醇 --> 钠 -
  • 下游产品:6-(1H-吡唑-1-基)烟酰腈 --> 2-四氢吡喃-4-乙醇 --> 环辛酮 --> 5-氯-2-甲基苯并噻唑 --> 替马沙星 --> 沙拉沙星 --> 菲宁达 --> 5-氟吲哚-2-酮 --> (6-(1H-吡唑-1-基)吡啶-3-基)甲醇 --> (R)-苄氧甲基环氧乙烷 --> 亚精胺 --> 3-氨基苯并呋喃-2-甲酸乙酯 --> 2-甲基嘧啶-4-醇 --> 3-氨基-2,2-二甲基-1-丙醇 --> 7-甲基-1,6-辛二烯 --> 硝酸舍他康唑 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 2,4-二苄氧基-

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