1,1,1,3,3,3-hexafluoropropan-2-ol 六氟异丙醇

CAS 920-66-1 MFCD00011651

化学结构图

920-66-1
SMILES: OC(C(F)(F)F)C(F)(F)F

化学属性

Mol. FormulaC3H2F6O
Mol. Weight168.04
Boiling Point59
TSCAT
Melting Point-4
Density1.596
Refractive indexn20/D 1.275(lit.)
Flash Point4,4°C
Appearance 白色透明液体,六氟异丙醇是一种特种含氟材料,密度高、粘度低、表面张力低。其在紫外光( <;2000A )下呈透明 , 且折射系数低。可与水或大多数有机溶剂以任意比例互溶,但不溶于长链的烷烃。熔点 −4 ℃ ,沸点 59 ; ℃ ,密度 1.596 ;g/mL ;at 25 ℃ ,折光率 n 20/D 1.275 ,闪点 4.4 ℃ ,水中溶解度1000 g/L 六氟异丙醇具有强氢键,可与大多数分子结合,并与多种的醚和胺形成稳定的、难以用分馏分离的结合物。
SolubilitySoluble in water (1000 mg/ml at 25 °C), chloroform, ether, and acetone.
Mol. FormulaC3H2F6O
Mol. Weight168
Density1.596
Appearance colorless liq.
Boiling Point59
Melting Point-4

别名和识别编码

Chemical Name1,1,1,3,3,3-hexafluoropropan-2-ol
CAS Number920-66-1
Alfabeta NameHEXAFLUOROPROPANOL 1113332---,,,,,
MDL NumberMFCD00011651
EC Number213-059-4
Beilstein Registry Number1841007
Synonym 1,1,1,3,3,3-HEXAFLUORO PROPAN-2-OL 1,1,1,3,3,3-HEXAFLUOROPROPANOL 1,1,1,3,3,3-Hexafluoroisopropanol 1,1,1,3,3,3-hexafluoro-2-propanolakahfip,hexafluoroisopropanol 1,1,1,3,3,3-六氟代-2-丙醇 1,1,1,3,3,3六氟-2-异丙醇 1,1,1,3,3,3六氟-2-异丙醇;HFP;HFIP;1,1,1,3,3,3-六氟-2-丙醇;1,1,1,3,3,3-六氟代-2-丙醇;1,1,1,3,3,3-六氟异丙醇 Bis(trifluoromethyl)methanol Ethanol, 2,2,2-trifluoro-1-(trifluoromethyl)- F6IPROH HEXAFLUORO-2-PROPANOL HEXAFLUORO-2-PROPYLALCOHOL HEXAFLUOROISOPROPANOL HFP 六氟异丙醇 Hexafluoroisopropanol 六氟异丙醇 六氟异丙醇 HFIP 六氟異丙醇
PubChem Substance ID13529
Chemical Name Translation六氟异丙醇
Reaxys-RN1841007
Wiswesser Line NotationFXFFYQXFFF
LabNetwork Molecule IDLN00009280
InChIInChI=1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
MDL NumberMFCD00011651
CAS Number920-66-1
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分类

  • {SNA} Derivatization Reagents, Derivatization Reagents GC, Reagents for Alkylation & Esterification,
  • {SNA} Chromatography Reagents & Solvents, LC-MS Mobile Phase Additives, LC-MS Solvents & Reagents (CHROMASOLV), 分析/色谱, 分析试剂
  • {SNA} Analytical Reagents, Analytical/Chromatography, Derivatization Reagents, Derivatization Reagents GC, Reagents for Alkylation & Esterification
  • {SNA} Chemical Reagents, Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Development Quantities for Research, Organic Building Blocks, Oxygen Compounds
  • {SNA} Derivatizatio
  • {SNA} Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, LC-MS Mobile Phase Additives, LC-MS Solvents & Reagents (CHROMASOLV)

产品应用

  • Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.

相关文献及参考

  • The esters formed with N-protected amino acids have been investigated as active intermediates in peptide synthesis: J. Org. Chem., 44, 4577 (1979). See Appendix 6.
  • Lithiation generates the useful synthon lithium perfluoropropenolate: Org. Synth., 76, 151 (1998):
  • The mildly acidic character (pKa 9.3) has been exploited in the selective deprotection of the 4,4'-dimethoxytrityl group in acid-sensitive nucleosides and nucleotides without competing N-gly
  • Effective solvent for uncatalyzed epoxidations of alkenes with H2O2 (caution! 60%): Synlett, 248 (2001); or, more conveniently, Urea hydrogen peroxide adduct, L13940: Eur. J. Org. Chem., 3290 (2002). Superior reaction medium for epoxidations, catalyzed by Hexafluoroacetone trihydrate, L10777: Synlett, 1305 (2001). An efficient, selective oxidation of sulfides to sulfoxides with 30% H2O2 employs HFIP as solvent, avoiding over-oxidation to the sulfone: Tetrahedron Lett., 39, 3141 (1998). For a review of fluorinated alcohols as solvents for selective and clean reactions, see: Synlett, 18 (2004).
  • Valuable solvent of high polarity and low nucleophilicity: Tetrahedron Lett., 2335 (1974). Extremely powerful H bond donor but poor H bond acceptor: anions are highly solvated, but cations poorly. For feature article on the use of this unique solvent in the stabilization of radical cations, with particular application to EPR spectroscopy, see: Chem. Commun., 2105 (1996). Preferred solvent for the direct substitution of phenol ethers promoted by [Bis(trifluoroacetoxy)­iodo]benzene, L15141: Tetrahedron Lett., 32, 4321 (1991). The intermediacy of radical cations in this reaction has been demonstrated: J. Am. Chem. Soc., 116, 3684 (1994). See also: J. Org. Chem., 60, 7144 (1995).
  • Powerful solvent for oligopeptides: Bull. Chem. Soc. Jpn., 61, 281 (1984); 66, 494 (1993). Used alone as a peptide coupling medium, HFIP gives poor results, but as a cosolvent along with proton acceptors such as D

安全信息

Warnings IRRITANT, CORROSIVE
Signal word Danger
GHS Symbol
WGK Germany2
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P303+P361+P353
  • P304+P340+P312
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSUB6450000
Packing GroupII
UN Number 2922 UN 2922 8/PG 2
Hazard statements
  • H302+H332
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US)
Hazard Codes 8 C C,Xi
Hazard Class8
Storage condition Store at RT.
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 13,1215,1970

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1974 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Lungs, Thorax, or Respiration - dyspnea
   Blood - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571423

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 13,1215,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Abe

其他信息

  • Sigma Aldrich:920-66-1(sigmaaldrich)
  • TCI Shanghai:1,1,1,3,3,3-六氟-2-丙醇 1,1,1,3,3,3-Hexafluoro-2-propanol,>;99.0%(GC)(920-66-1)
  • 图谱信息:1,1,1,3,3,3-六氟代-2-丙醇(920-66-1)红外图谱(IR1) 1,1,1,3,3,3-六氟代-2-丙醇(920-66-1)核磁图( 1 HNMR) 1,1,1,3,3,3-六氟代-2-丙醇(920-66-1)质谱(MS)
  • Alfa Aesar:1,1,1,3,3,3-六氟代-2-丙醇,99% 1,1,1,3,3,3-Hexafluoro-2-propanol, 99+%(920-66-1)
  • 海关编码:29055910
  • 下游产品:七氟烷
  • TSCA:T
  • 上游原料:溴氰
  • 六氟异丙醇是一种特种含氟材料,密度高、粘度低、表面张力低。其在紫外光( <2000A )下呈透明 , 且折射系数低。可与水或大多数有机溶剂以任意比例互溶,但不溶于长链的烷烃。水中溶解度:1000 g/L (25°C)
  • MSDS 信息:1,1,1,3,3,3-Hexafluoro-2-propanol(920-66-1).msds
  • Acros Organics:1,1,1,3,3,3-六氟-2-丙醇 1,1,1,3,3,3-Hexafluoro-2-propanol, pure, 99.5+%(920-66-1)
  • Hazard Note:Corrosive
  • 六氟异丙醇:六氟异丙醇 (简称:HFIP)是一种黏稠的、具有刺激性气味的无色液体。它是溶解聚酰胺和酯类的理想溶剂,可用于分析尼龙。通常情况下,可以在洗脱液中添加少量的三氟醋酸钠以减少样品的聚集。HFIP 虽然有一定的黏度但其沸点很低,通常需要在40 °C条件下进行分析以减少色谱柱的背压。六氟异丙醇还是一种高极性的溶剂,会使混合柱床色谱柱得到的校正曲线变得非线性。因此,安捷伦研发了一种用于该溶剂的特殊的色谱柱—PL HFIPgel 色谱柱,它具有不受溶剂影响的多孔性结构。
  • 1,1,1,3,3,3-六氟代-2-丙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1274703 1,1,1,3,3,3-六氟-2-丙醇;1,1,1,3,3,3-六氟异丙醇;六氟异丙醇 100g 1900元 2011/08/23 K5251201 1,1,1,3,3,3-六氟-2-丙醇;1,1,1,3,3,3-六氟异丙醇;六氟异丙醇 25ml 964元 2011/08/23 40080080 1,1,1,3,3,3-;六氟-2-丙醇 25ml 1316元
  • 检测方法:GC,NMR
  • MOL 文件:920-66-1.mol
  • F:27
  • 六氟异丙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1274703 1,1,1,3,3,3-六氟-2-丙醇;1,1,1,3,3,3-六氟异丙醇;六氟异丙醇 100g 1900元 2011/08/23 K5251201 1,1,1,3,3,3-六氟-2-丙醇;1,1,1,3,3,3-六氟异丙醇;六氟异丙醇 25ml 964元 2011/08/23 40080080 1,1,1,3,3,3-;六氟-2-丙醇 25ml 1316元
  • 用途一:酯化作用试剂,肽和肽中间体的高强溶剂。使用GLC和电子捕获检测测定组织中的芳香酸.也可作为溶剂或清洗剂用于电子行业。其还凭借其可溶解各种聚合物(包括聚酯、聚酰胺、聚丙烯腈、聚缩醛树脂、和水解聚乙烯酯等)的能力而用于大量这些产品的分析中。

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