N-(2-Chloro-5-Methoxyphenyl)-6-Methoxy N-(2-氯-5-甲氧基苯基)-6-甲氧基

CAS 476159-98-5 MFCD76159985

化学结构图

476159-98-5
SMILES: COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1

化学属性

Mol. Weight442.94
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameN-(2-Chloro-5-Methoxyphenyl)-6-Methoxy
FormulaC23H27ClN4O3
Synonym AZM475271; AZM-475271; AZM 475271.
IUPAC NameN-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
InChIKeyWPOXAFXHRJYEIC-UHFFFAOYSA-N
InChIInChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27)
Canonical SMILESCN1CCC(COC2=CC3=NC=NC(NC4=CC(OC)=CC=C4Cl)=C3C=C2OC)CC1
Chemical Name TranslationN-(2-氯-5-甲氧基苯基)-6-甲氧基
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产品应用

  • AZM475271 is orally Src tyrosine kinase inhibitor with potential anticancer and antimetastatic activities. Chemical structurally, AZM-475271 is the 4-amino-quinazoline based anticancer agent. AZM475271 remarkably inhibits growth and metastasis of orthotopically implanted human pancreatic carcinoma cells in nude mice. AZM475271 suppresses tumor growth and metastasis in vitro and in vivo potentially by anti-angiogenic mechanisms.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Src

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