Clofenotane p,

CAS 50-29-3 MFCD00000802

化学结构图

50-29-3
SMILES: Clc1ccc(C(c2ccc(Cl)cc2)C(Cl)(Cl)Cl)cc1

化学属性

Mol. FormulaC14H9Cl5
Mol. Weight354
Melting Point108-109°C
Flash Point72 °C
Solubility不溶于水，易溶于丙酮、苯、二氯乙烷。
Density1.0
Stability对光敏感
Boiling Point260°C

别名和识别编码

Chemical Namep’-DDT标准溶液 p, p’-DDT solution
CAS Number50-29-3
Synonym ######## 1 1,1'-(2,2,2-trichlorethylidene)bis(4-c 1,1,1-TRICHLORO-2,2-BIS(4-CHLOROPHENYL)ETHANE 1,1,1-TRICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHANE 1,1,1-TRICHLORO-2,2-DI(4-CHLOROPHENYL)ETHANE 1,1,1-Trichloro-2,2-di(p-chlorophenyl)ethane 1,1,1-Tricloro-2,2-bis(4-cloro-fenil)-etano 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane 1,1,1-trichloro-2,2-bis-(4-chloro-phenyl)-ethane 1,1-BIS(4-CHLOROPHENYL)-2,2,2-TRICHLOROETHANE 1,1-Bis(p-chlorophenyl)-2,2,2-trichloroethane 1,1-双(4-氯苯基)2,2,2-三氯乙烷 2 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane, p,p'-DDT 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane 2,2-双(4-氯苯基)-1,1,1-三氯乙烷(即P,P'-DDT) 2,2-双(4-氯苯基)-1,1,1-三氯乙烷,1,
PubChem Substance ID3036
EC Number200-659-6
Beilstein Registry Number1882657
MDL NumberMFCD00000802
Chemical Name Translationp,
Merck Number13,2861
Wiswesser Line NotationGXGGYR DG&R DG
InChIInChI=1S/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H
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分类

  • Acaricides, Analytical Standards, Analytical/Chromatography, Aryl, Bioactive Small Molecules, Building Blocks, C13 to C37+, Cell Biology, Chemical Synthesis, Chromatography, D-DIF, Environmental Standards, Halogenated Hydrocarbons, Organic Building Blocks, Pesticides, Pesticides & Metabolites
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SA} Acaricides, Analytical Standards, Analytical/Chromatography, Aryl, Bioactive Small Molecules, Building Blocks, C13 to C37+, Cell Biology,
  • {SNA} Acaricides,

产品应用

  • 用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。主要用于环境监测，仪器卫生监督、商品检验等方面对于农药残毒的分析测试工作。

相关文献及参考

  • Short: III/20b
  • Short: III/31a
  • Short: III/10a
  • Merck: 14,2841
  • Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989);
  • Merck: 14,2841 Beilstein: 5,IV,1885

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H351 Suspected of causing cancer 怀疑致癌
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T,N T,N,Xi,F
RTECSKJ3325000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P302+P352
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P337+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S33 Take precautionary measures against static discharges 对静电采取预防措施；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R25 Toxic if swallowed 吞咽有毒
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R48/25
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R50/53
  • R52/53
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
Storage condition APPROX 4°C 低温(<10˚C)及避光保存。 储存温度 2-8℃ 储存温度2-8℃
UN Number UN 2811 6.1/PG 3
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 19 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Blood - lymphoma, including Hodgkin

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1225 mg/kg/7W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   TUMOAB Tumori.  (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
   Italy)  V.1-    1911-  Volume(issue)/page/year: 6

{

{hazar

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 17976 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   TUMOAB Tumori.  (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
   Italy)  V.1-    1911-  Volume(issue)/page/year: 68,11,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3408 mg/kg
                          multigenerations
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 11,688,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AVPCAQ Advances in Pharmacology and Chemotherapy.  (Academic Press, Inc., 1
   E. First St., Duluth, MN 55802)  V.7-20, 1969-84.  Volume(issue)/page/year:
   12,31,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PESTD5 Proceedings of the European Society of Toxicology.  (Amsterdam,
   Netherlands)  V.16-18, 1975-77.  Discontinued.  Volume(issue)/page/year:
   17,351,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,845,1945

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK

{

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 500 mg/kg
T

TYPE OF TEST

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 15 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issu

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   HOEKAN Hokkaidoritsu Eisei Kenkyushoho.  Report of the Hokkaido Institute of
   Public Health.  (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) 
   No.1-    1951-  Volume(issue)/page/year: 29,33,1979

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 17(3),32,1973

{haz

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 gm/kg
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 51,605,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 ug
REFERENCE :
   AJBSAM Australian Journal of Biological Sciences.  (Commonwealth Scientific
   and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic.
   3002, Australia)  V.6-    1953-  Volume(issue)/page/year: 27,427,1974

TYPE OF TEST            : DNA adduct
TEST SYSTEM

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 418 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 504 mg/kg
SEX/DURATION            : lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   ENPBBC Environmental Physiology and Biochemistry.  (Copenhagen, Denmark)
   V.2-5, 1972-75. Discontinued.  Volume(issue)/page/year: 4,189,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - ra

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 81 mg/kg
SEX/DURATION            : male 4 week(s) pre-mating
                          female 4 week(s) pre-mating  - 2 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,54,1967

TYPE OF TEST            : TDLo - Lowest published to

其他信息

  • 用途:具有胃毒和触杀作用，属高残留农药品种，用于防治多种昆虫和卫生害虫
  • 易溶于吡啶及二氧六环。在100ml溶剂中溶解度
  • 图谱信息:2,2-双(对氯苯基)-1,1,1-三氯乙烷 (50-29-3)核磁图( 1 HNMR) 2,2-双(对氯苯基)-1,1,1-三氯乙烷 (50-29-3)Raman光谱 2,2-双(对氯苯基)-1,1,1-三氯乙烷 (50-29-3)红外图谱(IR1) 2,2-双(对氯苯基)-1,1,1-三氯乙烷 (50-29-3)核磁图( 13 CNMR) 2,2-双(对氯苯基)-1,1,1-三氯乙烷 (50-29-3)质谱(MS) 2,2-双(对氯苯基)-1,1,1-三氯乙烷 (50-29-3)红外图谱(IR2)
  • 杀虫剂单一组分标准液
  • 易溶于吡啶及二氧六环。在100ml溶剂中溶解度分别为：丙酮58g，四氯化碳45g，氯苯74g，乙醇2g，乙醚28g。不溶于水、稀酸和碱液。
  • RTECS号:KJ3325000
  • 稳定性:Stable. Combustible. Incompatible with strong oxidizing agents, iron and aluminium and their salts, alkalies.
  • MOL 文件:50-29-3.mol
  • 生产方法:由三氯乙醛与一氯化苯在发烟硫酸存在下缩合而得。在缩合锅中投入三氯乙醛、氯苯，搅拌下滴加发烟硫酸。缩合后的物料静置分层，放净废酸，酸性滴滴涕氯苯溶液用热水洗涤，再用氢氧化钠溶液洗涤。然后蒸馏回收氯苯，残留物即熔融的滴滴涕放至滚筒结晶器冷却结晶即得成品。缩合反应在10-23℃进行，缩合中同时加入缩合反应产生的废酸（内含副反应生成的对氯苯磺酸）或抑制副反应，减少对氯苯磺酸的生成量，滴加硫酸的时间约2.5h。一级品的滴滴涕原粉对位含量≥74.0%。
  • PackingGroup:III
  • HazardClass:6.1(b)
  • 外观性质:白色或淡黄色粉末。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. D-DIF - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides &amp; Metabolites - Environmental Standards
  6. Pesticides - Pesticides &amp; Metabolites
  7. Acaricides - Pesticides
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides &amp; Metabolites - Environmental Standards
  6. Pesticides - Pesticides &amp; Metabolites
  7. Acaricides - Pesticides
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  6. C13 to C37+ - Aryl
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. D - Alphabetic
  5. DA - DH - D
  1. Analytical & Chromatography 分析化学与色谱
  2. Environmental Endocrine Disruptors

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