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分类

• {SNA} 12 Principles Aligned Products, Alternative Energy, Chemical Synthesis, Greener Alternative Products, Material Sciences, Materials for Hydrogen Storage, Metal Hydrides, Reduction, Synthetic Reagents, 材料科学
• {SNA} Alternative Energy, Chemical Synthesis, Materials Science, Materials for Hydrogen Storage, Metal Hydrides, Reduction, Synthetic Reagents
• {SNA} Alternative Energy, Chemical Synthesis, Enabling Products, Greener Alternative Products, Material Sciences, Materials for Hydrogen Storage, Metal Hydrides, Reduction,
• {SNA} Alternative Energy,

产品应用

• 在有机合成中用作还原剂、缩合剂、烷基化试剂、氢化催化剂、克莱逊氏试剂，用作释氢剂。

相关文献及参考

• Short: II/24C
• CAUTION! Many literature procedures employ NaH in DMF, and this system is often used routinely by research workers as a 'convenient' general purpose strong base. It should be noted, especially when considering scale-up of such reactions, that thermal runaways have been observed with NaH/ DMF, with self-heating beginning at temperatures as low as 26oC in some cases: Chem. Eng. News, 60(28), 5; 60(37), 5 (1982). A similar effect was also noted with N,N-dimethylacetamide. More recently also, incidents have been reported with other dipolar aprotic solvents 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) and Dimethyl sulfoxide (DMSO): Org. Process. Res. Dev., 7, 1030 (2003).
• Short: II/24A
• For a review of sodium hydride-based complex reducing agents, see: Acta Chem. Scand., 44, 274 (1990).
• Merck: 14,8625
• Widely used strong base for the irreversible formation of Na derivatives. If required, the protective oil can be removed by repeated washing and decantation with low-boiling petroleum, see, e.g.: Org. Synth. Coll., 6, 684 (1988), but for many purposes, this is not necessary, and the oil can be removed by incorporating a suitable extraction or washing step in the work-up. There are numerous Organic Syntheses references to reactions using NaH.
• Used in the deprotonation of DMSO to form "dimsyl sodium", a useful strong base for e.g. the Wittig reaction: J. Org. Chem., 28, 1128 (1963).

安全信息

GHS Symbol

其他信息

• Acros Organics:Sodium hydride, dispersion in mineral oil, 75%(7646-69-7)
• {Chem
• {
• 氢化钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 C332141000 氢化钠 100g 460元 2011/08/23 C332145000 氢化钠 500g 1182元 2011/08/23 K7162002 氢化钠55-65％，purum 100g 485元
• 储运特性:库房通风
• 理化性质:氢化钠属于离子晶体，类盐化合物，其中氢为负一价离子。加热
• MSDS 信息:7646-69-7.msds
• 上游原料:甲醇 --> 钠 --> 氢
• 可燃性危险特性:遇水、湿空气放出氢气可燃
• Sigma Aldrich:7646-69-7(sigmaaldrich)
• 下游产品:6-(1H-吡唑-1-基)烟酰腈 --> 2-四氢吡喃-4-乙醇 --> 环辛酮 --> 5-氯-2-甲基苯并噻唑 --> 替马沙星 --> 沙拉沙星 --> 菲宁达 --> 5-氟吲哚-2-酮 --> (6-(1H-吡唑-1-基)吡啶-3-基)甲醇 --> (R)-苄氧甲基环氧乙烷 --> 亚精胺 --> 3-氨基苯并呋喃-2-甲酸乙酯 --> 2-甲基嘧啶-4-醇 --> 3-氨基-2，2-二甲基-1-丙醇 --> 7-甲基-1，6-辛二烯 --> 硝酸舍他康唑 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 2,4-二苄氧基-5-溴嘧啶 --> 4-甲氧基乙酰乙酸乙酯 --> 3-氨基-呋喃并[2,3-B]嘧啶-2-甲酸乙酯 --> 2,2-二甲基环己酮 --> 1-苄基-2-甲基咪唑 --> 甲基柏木醚 --> 6-吡唑-1-基烟酸甲酯 --> 3,5-二氟苯乙酸 --> 2,4,6-三(2-吡啶基)三嗪 --> 氟司喹南 --> 氯康唑 --> 烟酰乙酸甲酯
• 外观性质:白色至淡灰色的细微结晶，以25-50%比例分散在油中。
• 以25%-50%比例分散在油中，氢化钠制成品是一个氢化钠在矿物油中的50~80的微晶分散体。典型粒度范围为5-50微米。在800°C熔化同时分解，不溶于液氨、苯、二硫化碳、四氯化碳、熔融的氢和其它有机溶剂；在室温下的干燥空气或氧气中稳定，在潮湿空气中极易水解；遇水剧烈反应。
• TCI Shanghai:氢化钠(60%,分散于液状石蜡) Sodium Hydride (60%, dispersion in Paraffin Liquid)(7646-69-7)
• 类别:遇水燃烧物品
• Alfa Aesar:氢化钠,57-63%oildispersion Sodium hydride, 57-63% oil dispersion(7646-69-7)
• 以25%-50%比例分散在油中，氢化钠制成品是一个氢化钠在矿物油中的50~80的微晶分散体。典型粒度范围为5-50微米。在800°C熔化同时分解，不溶于液氨、苯、二硫化碳、四氯化碳、熔融的氢和其它有机溶剂；在室温下的干燥
• 敏感性:Air & Moisture Sensitive
• 用途二:在有机合成中用作还原剂、缩合剂、烷基化试剂、氢化催化剂、克莱逊氏试剂，用作释氢剂。
• 存储注意事项:湿度敏感;氮气保护
• {Chemicalbook
• 上游原料:甲醇 --> 钠 -
• 下游产品:6-(1H-吡唑-1-基)烟酰腈 --> 2-四氢吡喃-4-乙醇 --> 环辛酮 --> 5-氯-2-甲基苯并噻唑 --> 替马沙星 --> 沙拉沙星 --> 菲宁达 --> 5-氟吲哚-2-酮 --> (6-(1H-吡唑-1-基)吡啶-3-基)甲醇 --> (R)-苄氧甲基环氧乙烷 --> 亚精胺 --> 3-氨基苯并呋喃-2-甲酸乙酯 --> 2-甲基嘧啶-4-醇 --> 3-氨基-2，2-二甲基-1-丙醇 --> 7-甲基-1，6-辛二烯 --> 硝酸舍他康唑 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 2,4-二苄氧基-