Cortexolone 脱氧可的松

CAS 152-58-9 MFCD00003662

化学结构图

152-58-9
SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO

化学属性

Mol. FormulaC21H30O4
Mol. Weight346
Melting Point208 °C (dec.)(lit.)
Refractive index120 ° (C=1, Dioxane)

别名和识别编码

Chemical NameCortexolone
CAS Number152-58-9
Synonym 11-DESOXY-17-HYDROXYCORTICOSTERONE 17ALPHA-HYDROXYCORTEXONE {Chem 17,21-dihyd Cortisol, 11-deoxy- 11-Deoxycortisol CORTODOXONE 17ALPHA,21-DIHYDROX Cortifen REICHSTEIN'S SUBSTANCE 'S' Pregn-4-ene-3,20-dione, 17,21-dihydroxy- 脱氧皮醇 Cortexolone 11-Deoxy-17-hydroxycorticosterone 11-DEOXY-17-HYDROXYCORTICOSTERONE (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 11-Deoxy-17-hydroxycorticosterone 11-Deoxycortisol 17α,21-Dihydroxy-4-pregnene-3,20-dione 17α-Hydroxycortexone 17,21-Dihydro Reichstein S 17,21-Dihydroxyprogesterone 17,21-Dihydroxy-4-pregnene-3,20-dione Reichstein's substance S 17α,21-Dihydroxy-4-pregnene-3,20-dione 17-羥-11-去氧皮甾酮 11-Desoxy-17α-hydroxycorticosterone 17,21-DIHYDROXY-4-PREGNENE-3,20-DIONE Reichstein’s substance S 11-Desoxy-17-hydroxycorticosterone 11-Deoxyhydrocortisone cortodoxone (INN) NSC-18317 Corticosterone, 11-deoxy-17-hydroxy- Cortodoxo 11-DEOXYCORTISOL SKF 3050 11-Desoxyhydrocortisone Reichstein's compound S 11-Desoxycortisol 17ALPHA,21-DIHYDROXYPREGNA-4-ENE-3,20-DIONE Reichstein's Compound S {uni_ 11-Deoxycortisone 17,21-Dihydroxypregn-4-ene-3,20-dione {h 17-Hydro Reichstein’s Compound S 4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE 17α-Hydroxycortexone
MDL NumberMFCD00003662
PubChem Substance ID440707
EC Number205-805-2
Reaxys-RN2511358
Beilstein Registry Number8(4)2913
Merck Number2932
Chemical Name Translation脱氧可的松
Wiswesser Line NotationL E5 B666 OV MUTJ A1 E1 FV1Q FQ
LabNetwork Molecule IDLN00202133
InChIInChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
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分类

  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, R, Steroid Hormones
  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, R, Steroid Hormones,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, R, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Cytokines, Growth Factors and Hormones, Hormones,
  • {SNA} Cytokines, Growth Factors

产品应用

  • Glucocorticoid receptor binding

相关文献及参考

  • Gazdar, A., et al.: Cancer Res., 50, 5488
  • Reichstein, T. and Shoppee, C.W. Vitam. Horm. 1 , 346, (1943)
  • Merck 14 ,2932
  • Corp MSDS 1 (2), 3036:D / FT-IR 2 (3), 4232:D / FT-IR 1 (2), 1054:C / FT-NMR 1 (3), 584:B / IR-Spectra (3), 1498:B / IR-Spectra (2), 1281:C / NMR-Reference 2 (2), 926:A / RegBook 1 (2), 2863:F / Sigma FT-IR 1 (1), 1317:A / Structure Index 1 , 458:C:6
  • Short: II/27C Title: Diamagnetic Susceptibility and Magnetic Anisotropy of Organic Compounds Author: Kumar, Mahendra; Gupta, Rajni Editor: Gupta, Radha Raman Source: Landolt-Börnstein, New Series Volume: II/27C Year: 2008 Keyword: diamagnetic susceptibility; magnetic anisotropy; organic compounds ISBN: 978-3-540-44734-4 (print) ISBN: 978-3-540-44736-8 (online) Internet Resource: doi:10.1007/978-3-540-44736-8 RefComment: VIII, 204 p., Hardcover RefComment: Written for: Scientists and researchers in the fields of physics, chemistry, materials science RefComment: Supplement and Revised Editon to II/16 Abstract: The volume II/27 has been divided into three subvolumes according to the classes of compounds: Subvolume A: Diamagnetic susceptibility and magnetic anisotropy of inorganic and organometallic compounds; Subvolume B: Diamagnetic susceptibility of organic compounds (Part 1); Subvolume C: Diamagnetic susceptibility and magnetic anisotropy of organic compounds (Part 2). The data presented in this volume are based on the literature survey of the chemical abstracts up to 2005.
  • Short: III/35E Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Oxygen-17 Author: Duddeck, H.; Toth, G.; Simon, A. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35E Year: 2002 Keyword: Alipathic and Aromatic hydrocarbons; Coupling constant j; Nuclear Magnetic Resonance; chemical shifts δ ISBN: 3-540-42501-2 ISBN: 978-3-540-42501-4 Internet Resour

安全信息

WGK Germany3
RTECSTU5011500
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04684

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996

其他信息

  • TCI Shanghai:脱氧可的松 Cortexolone,>;98.0%(LC)(152-58-9)
  • MOL 文件:152-58-9.mol
  • 图谱信息:脱氧可的松(152-58-9)红外图谱(IR2) 脱氧可的松(152-58-9)质谱(MS) 脱氧可的松(152-58-9)核磁图( 13 CNMR) 脱氧可的松(152-58-9)红外图谱(IR1)
  • Acros Organics:脱氧皮醇 Cortexolone, 99%(152-58-9)
  • Sigma Aldrich:152-58-9(sigmaaldrich)
  • 脱氧可的松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1478 脱氧可的松 Cortexolone 1G 452元

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Progesterone - Steroid Hormones
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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