(R)-Malic acid D-苹果酸

CAS 636-61-3 MFCD00004245

化学结构图

636-61-3
SMILES: O=C(O)CC(O)C(=O)O

化学属性

Mol. FormulaC4H6O5
Mol. Weight134.09
Density1.60
Melting Point98-102°C
TSCANo
Solubility可溶
Refractive index6.5 ° (C=10, Acetone)
Stability对光敏感
Boiling Point306.4°C at 760 mmHg

别名和识别编码

Chemical Name(R)-Malic acid
CAS Number636-61-3
Synonym D-(+)-Malic acid {LY} D-(+)-Malic acid {} {LY} D-(+)-Malic acid {} {} {LY} D-(+)-Malic acid {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} D-(+)-Malic acid {} {} {} {} {
MDL NumberMFCD00004245
EC Number211-262-2
Beilstein Registry Number1723540
Merck Number5707
PubChem Substance ID87572139
Reaxys-RN1723540
Chemical Name TranslationD-苹果酸
Wiswesser Line NotationQVYQ1VQ
LabNetwork Molecule IDLN00008386
InChIInChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m1/s1
Canonical SMILESO=C(O)[C@H](O)CC(O)=O
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分类

  • Chiral Reagents
  • {SNA} Asymmetric Synthesis, Carboxylic Acids, Chemical Synthesis, Chiral Building Blocks, Chiral Resolution Reagents, Chiral Resolving Reagents, Organic Building Blocks
  • Aliphatics
  • {SNA} Analytical Standards, Analytical/Chromatography, Biochemicals and Reagents, Chromatography, Fatty Acids, Food & Beverage Standards, Lipid Analytical Standards, Lipids, Organic Acids, Other Lipid Related Products

产品应用

  • 一种极其重要的四碳有机手性源。主要应用于手性药物、手性添加剂、手性助剂等领域，它在制药及食品行业作为手性合成的手性源，作为一种光学活性的有机酸，它在某些手性化合物的不对称合成过程中具有不可替代的作用。

相关文献及参考

  • Rindi, G., et al.: Biochem. J., 80, 214
  • Merck: 14,5707 Beilstein:3(4)1123
  • Merck: 14,5707

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P310
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSON7260000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   15,628,1923

其他信息

  • D-(+)-苹果酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M0021 D-(+)-苹果酸 D-(+)-Malic Acid 25G 1590元 2011/04/16 M0021 D-(+)-苹果酸 D-(+)-Malic Acid 5G 526元 2010/06/21 153500050 D-(+)-苹果酸 D(+)-Malic acid 98% 5 GR 858元
  • Alfa Aesar:D-(+)-苹果酸,98+% D-(+)-Malic acid, 98+%(636-61-3)
  • TCI Shanghai:D-(+)-苹果酸 D-(+)-Malic Acid,>;98.0%(GC)(T)(636-61-3)
  • Acros Organics:D-苹果酸 D(+)-Malic acid, 98%(636-61-3)
  • 检测方法:T,NMR,M.P
  • 下游产品:(R)-3-羟基吡咯烷盐酸盐 --> (R)-(+)-N-苄基-3-羟基吡咯烷 --> (R)-3-吡咯烷醇 --> (S)-(+)-3-喹宁醇
  • 外观性质:白色结晶颗粒或结晶粉末。易溶于水，醇等有机溶剂。水溶液呈酸性。熔点：99-104℃
  • MOL 文件:636-61-3.mol
  • MSDS 信息:D(+)-Malic acid(636-61-3).msds
  • 比旋光度:2.2 ° (c=3, H2O)
  • 易溶于水，醇等有机溶剂。水溶液呈酸性。
  • Sigma Aldrich:636-61-3(sigmaaldrich)
  • D-(+)-苹果酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0021 D-(+)-苹果酸 D-(+)-Malic Acid 25G 1930元 2014/06/02 M0021 D-(+)-苹果酸 D-(+)-Malic Acid 5G 637元 2010/06/21 153500050 D-(+)-苹果酸 D(+)-Malic acid 98% 5 GR 858元
  • 用途二:一种极其重要的四碳有机手性源。主要应用于手性药物、手性添加剂、手性助剂等领域，它在制药及食品行业作为手性合成的手性源，作为一种光学活性的有机酸，它在某些手性化合物的不对称合成过程中具有不可替代的作用。
  • 图谱信息:D-(+)-苹果酸(636-61-3)红外图谱(IR1)
  • 海关编码:29181980
  • 用途一:用于手性药物、手性添加剂、手性助剂等

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Resolution Reagents - Asymmetric Synthesis
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Organic Acids - Food & Beverage Standards
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Resolution Reagents - Asymmetric Synthesis
  4. Chiral Resolving Reagents - Chiral Resolution Reagents
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Carboxylic Acids - Organic Building Blocks
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Carboxylic Acids - Organic Building Blocks
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Other Lipid Related Products - Lipids
  5. Lipid Analytical Standards - Other Lipid Related Products
  6. Fatty Acids - Lipid Analytical Standards
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Optical Resolution
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carboxylic Acid Salts 羧酸盐
  1. Functional Group 官能团索引
  2. alpha-hydroxyacid

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