CAS 5704-04-1 MFCD00004277-Tricine 三(羟甲基)甲基甘氨酸 -LabNovo

Tricine 三(羟甲基)甲基甘氨酸

CAS 5704-04-1 MFCD00004277

化学结构图

SMILES: O=C(O)CNC(CO)(CO)CO

化学属性

Mol. Formula	C6H13NO5
Mol. Weight	179.17
Density	1.05
Melting Point	186-187
TSCA	Yes
Solubility	Soluble in water (89.6 g/l) at 20 °C.

别名和识别编码

Chemical Name	Tricine
CAS Number	5704-04-1
EC Number	227-193-6
Beilstein Registry Number	1937804
MDL Number	MFCD00004277
Synonym	Tricine {LY} Tricine tricine {} {LY} Tricine {} {} {LY} Tricine {} {} {} {LY} Tricine {} {} {} {} {LY} Tricine {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Tricine {} {} {} {} {} {} {} {} {} {} {}
Merck Number	9651
PubChem Substance ID	79784
Reaxys-RN	1937804
Chemical Name Translation	三(羟甲基)甲基甘氨酸
LabNetwork Molecule ID	LN00199271
InChI	InChI=1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
Canonical SMILES	O=C(O)CNC(CO)(CO)CO

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产品应用

A buffer component for separation of low molecular weight peptides.

安全信息

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard Codes Xi

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

溶于水。
溶于水。 pH range： 7.4 - 8.8 pKa (25 °C)： 8.1
生物缓冲剂组分，用于分离小分子量多肽。
Tricine is an organic derivative of tris and glycine used in buffer solutions. It is a zwitterionic amino acid with a useful buffering range of pH 7.4-8.8 and is one of Good's buffering agents; Good first prepared tricine to buffer chloropast reactions. A zwitterionic amino acid with a buffering range of pH 7.4-8.8. Due to a low negative charge and a high ionic strength, Tricine is very useful for electrophoretic separation of small molecular weight proteins in the range of 1 to 100 kDa. Tricine is a commonly used electrophoresis buffer and is also used in resuspension of cell pellets. It has a lower negative charge than glycine allowing it to migrate faster. In addition its high ionic strength causes more ion movement and less protein movement. This allows for low molecular weight proteins to be separated in lower percent acrylamide gels. Tricine has been documented in the separation of proteins in the range of 1 to 100 kDa by electrophoresis.[2] The tricine buffer at 25 mmol/L was found to be the most effective buffer among the ten tested for ATP assays using firefly luciferase.[3] Tricine has also been found to be an effective scavenger of hydroxyl radicals in a study of radiation-induced membrane damage. Buffer component for separation of low molecular weight peptides. A zwitterionic buffer useful in the pH range of 7.4-8.8. Has a pKa of 8.05 at 25°C.