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• 试剂商城
• 直接询价

分类

• Alkylation Reagents, Analytical Reagents, Analytical/Chromatography, Chelation/Complexation Compounds, Chemical Synthesis,
• {SNA} Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, Ion Chromatography Reagents, Salts and Additives for IC
• {SNA} Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Synthetic Reagents
• {uni_hamburg} no charge; oxygen heterocycle; alicycle; large ring; crown ether; 18ring; ether; 1fragment
• {SNA} Chromatography Reagents & Solvents, Ion Chromatography Reagents, Salts and Additives for IC, 分析/色谱, 分析试剂
• {SNA} 12 Principles Aligned Products, Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Greener Alternative Products, Synthetic Reagents

产品应用

• 大环醚类有机化合物。主要用途为精细有机合成用高效相转移催化剂、络合剂、贵金属和稀土元素分离提取用萃取剂。在化学分析中可用于离子的富集、分离和掩蔽，还可用于医药、生物化学领域以及电子工业中用作离子导电材料、液晶显示元件制作材料。

相关文献及参考

• Crown et
• Beil. 19 ,V,12,601
• Has been widely used in alkylation reactions with, e.g. K2CO3 as base:
• Has been used with KF to enhance the reactivity of F- as a base or a nucleophile, e.g. to promote Michael additions in aprotic solvents: J. Chem. Soc., Chem. Commun., 237 (1977), the condensation of nitromethane with aldehydes: Tetrahedron Lett., 3219 (1978), and the transesterification of diaryl to dialkyl phosphonates: Synthesis, 409, 412 (1982).
• Crown ether catalysis can be used in the reaction of KCN with alkyl halides to give nitriles: Tetrahedron Lett., 71 (1975), and for the preparation of acyl cyanides from acid chlorides: Tetrahedron Lett., 21, 2959 (1980). The 1:1 complex between 18-crown-6 and KCN has been used cata
• Crown ether (see Appendix 2) mainly used to complex potassium ions. For a comprehensive study of solvent effects on complexation with K ions in a wide range of solvents, see: J. Org. Chem., 61, 5221 (1996).
• Promotes methylation reactions with Dimethyl­ carbonate, A13104: Synthesis, 382 (1986). N-Alkylation of Glutarimide, L00968, and Succinimide, A13503: Bull. Soc. Chim. Fr., 227 (1992).
• Crown ether catalysis can be used in the reaction of KCN with alkyl halides to give nitriles: Tetrahedron Lett., 71 (1975), and for the preparation of acyl cyanides from acid chlorides: Tetrahedron Lett., 21, 2959 (1980). The 1:1 complex between 18-crown-6 and KCN has been used catalytically in the cyanosilylation of aldehydes, ketones and quinones with TMSCN; for examples, see: Org. Synth. Coll., 7, 517 (1990).
• Enables KH to metallate aryl-substituted methanes directly: J. Am. Chem. Soc., 99, 4457 (1977). In the presence of KOH in DME, various arylmethanes, benzyl alcohols and aldehydes are oxidized to carboxylic acids by molecular oxygen: Tetrahedron Lett., 25, 4989 (1984).

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 53(10),92,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0536187

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - other changes
   Liver - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.

其他信息

• 用途一:用作金属离子络合剂
• 用途三:大环醚类有机化合物。主要用途为精细有机合成用高效相转移催化剂、络合剂、贵金属和稀土元素分离提取用萃取剂。在化学分析中可用于离子的富集、分离和掩蔽，还可用于医药、生物化学领域以及电子工业中用作离子导电材料、液晶显示元件制作材料。
• TCI Shanghai:18-冠-6-醚 18-Crown 6-Ether,>;98.0%(GC)(17455-13-9)
• MOL 文件:17455-13-9.mol
• 检测方法:GC,NMR,MS
• 18-冠醚-6价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30203262 十八冠醚-6 100g 320元 2011/04/16 C0860 18-冠6-醚 18-Crown 6-Ether 100G 2460元 2011/04/16 C0860 18-冠6-醚 18-Crown 6-Ether 25G 880元
• MSDS 信息:Hexaoxacyclo-octadecane(17455-13-9).msds
• 上游原料:氰化钾 --> 碱金属 --> 15-冠醚-5 --> Γ-球蛋白 --> 有机碱 --> 生物化学
• 图谱信息:18-冠醚-6(17455-13-9)核磁图( 1 HNMR) 18-冠醚-6(17455-13-9)核磁图( 13 CNMR) 18-冠醚-6(17455-13-9)质谱(MS) 18-冠醚-6(17455-13-9)红外图谱(IR2) 18-冠醚-6(17455-13-9)红外图谱(IR1)
• 海关编码:29329995
• 用途二:冠醚最主要的特点之一，是可与各种金属盐、铵盐、有机阳离子化合物等形成稳定的络合物。利用这一性质，可将各种盐类溶于有机溶剂。冠醚可将阳离子螯环内，同时由于有朝外的有机基因可生成络合物，亦可溶于非极性的有机溶剂。这时，未被溶剂化的阴离子，以裸露的阴离子形式存在于溶剂中，故活性极大。冠醚可使碱金属和有机碱金属化合物溶解在有机溶剂中。因而在有机合成、光学拆分、重金属螯合、分离、分析以及生理活性的医药、生物化学等方面找到广泛的应用。例如，用作相转移催化剂，使许多在传统条件下难以反应，甚至不发生的反应，
• 存储注意事项:氮气保护
• 敏感性:Hygroscopic
• F:10
• Acros Organics:18-冠醚-6 18-Crown-6, 99%(17455-13-9)
• 下游产品:二甲基二茂铁 --> N,N-二甲基乙二胺 --> 5-溴吲唑 --> 3-苯氧基苯乙腈 --> 1,3-噻唑烷-2-酮 --> 头孢泊肟酯 --> 环氧十二烷 --> 2,4-二氨基-6-氟嘧啶 --> [(2-氧代-2H-苯并吡喃-7-基)氧基]乙酸 --> 4-甲基-3-氨基-2-氟吡啶 --> 2-氨基-4,6-二氟嘧啶 --> 2-(4-溴苯基)噻吩 --> 4-氨基-2,6-二氟嘧啶 --> N,N,N',N'-四苯基联苯胺
• 方法一:通常采用威廉林合成法制取，即用醇盐与卤代烷反应。 用途：冠醚最主要的特点之一，是可与各种金属盐、铵盐、有机阳离子化合物等形成稳定的络合物。利用这一性质，可将各种盐类溶于有机溶剂。冠醚可将阳离子螯环内，同时由于有朝外的有机基因可生成络合物，亦可溶于非极性的有机溶剂。这时，未被溶剂化的阴离子，以裸露的阴离子形式存在于溶剂中，故活性极大。冠醚可使碱金属和有机碱金属化合物溶解在有机溶剂中。因而在有机合成、光学拆分、重金属螯合、分离、分析以及生理活性的医药、生物化学等方面找到广泛的应用。例如，用作相转移催化剂，使许多在传统条件下难以反应，甚至不发生的反应，能顺利地进行，这类反应速率快、条件简单、操作方便、产率高。例如，安息香在水溶液中的缩合反应产率极低，如果在该水溶液中加入7%的冠醚，则可得到产率为78%的安息香。这一反应还可在苯（或乙腈）中进行，尽管氰化钾不溶于苯，但如果加入18-冠-6，则不仅能发生反应，而且产率可高达95%。18-冠-6的毒性：大鼠的口服致死量为300mg/kg。对眼睛、皮肤有刺激性。 #EndEditable "Content"