Maleimide 马来酰亚胺

CAS 541-59-3 MFCD00005494

化学结构图

541-59-3
SMILES: O=C1C=CC(=O)N1

化学属性

Mol. FormulaC4H3NO2
Mol. Weight97.07
Density1.249
Melting Point91-93°C
SolubilitySoluble in water
TSCAYes
Boiling Point244°C at 760 mmHg
Flash Point136.6±18.9 °C
Appearance 浅黄色结晶性粉末

别名和识别编码

Chemical NameMaleimide
CAS Number541-59-3
Synonym Maleimide {LY} Maleimide {} {LY} Maleimide {} {} {LY} Maleimide {} {} {} {LY} Maleimide {} {} {} {} {LY} Maleimide {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleimide {} {} {} {} {} {} {}
EC Number208-787-4
Beilstein Registry Number106910
MDL NumberMFCD00005494
PubChem Substance ID10935
Chemical Name Translation马来酰亚胺
Reaxys-RN106910
Wiswesser Line NotationT5VMVJ
LabNetwork Molecule IDLN00008691
InChIInChI=1S/C4H3NO2/c6-3-1-2-4(7)5-3/h1-2H,(H,5,6,7)
Canonical SMILESO=C(N1)C=CC1=O
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分类

  • {SNA} Building Blocks, Carbonyl Compounds, Chemical Synthesis, Cyclic Imides, Organic Building Blocks
  • Heterocycles
  • Miscellaneous Reagents
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 5ring; amide; lactame; 1fragment

产品应用

  • 用于有机合成。铑催化的和芳基硼酸的芳基化结合。

相关文献及参考

  • Short: II/25C
  • Stereoselective Diels-Alder reaction with an exocyclic diene has been used in the synthesis of a cyclohexannulated [5.3.1]propellane as a precursor of an ABC ring analogue of paclitaxel (Taxol): J. Chem. Soc., Chem. Commun., 1395 (1995).
  • Short: III/35E
  • Beilstein:21(5)10,3

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSON4800000
Packing GroupII
UN Number 2923 UN 2923 8/PG 2
Hazard Codes 8 T
Hazard Class8/6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 40(11),109,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - hemorrhage
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - other changes
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   27,151,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7766 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   37,15,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 750 ug/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   37,15,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3100 ug/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   37,15,1976

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • Sigma Aldrich:541-59-3(sigmaaldrich)
  • 用途一:用于有机合成。
  • 上游原料:重铬酸钾 --> 玻璃纤维
  • Acros Organics:顺丁烯二酰亚胺 Maleimide, 98%(541-59-3)
  • 用途二:用于有机合成。铑催化的和芳基硼酸的芳基化结合。
  • 马来酰亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0018 马来酰亚胺 Maleimide 25G 1670元 2014/06/02 M0018 马来酰亚胺 Maleimide 5G 497元 2010/06/21 156711000 马来酰亚胺 Maleimide 98% 100 GR 6497元
  • MOL 文件:541-59-3.mol
  • 溶于水、乙醇和乙醚。易升华。
  • TCI Shanghai:马来酰亚胺 Maleimide,>;98.0%(T)(541-59-3)
  • 方法一:由吡咯与重铬酸钾反应而得。将1177g重铬酸钾溶于1200ml水及712ml浓硫酸中,加热至35℃,将54g吡咯在搅拌下慢慢加入,反反温度不超过50℃。加毕,在40-50℃保温反应至无吡咯气味时为止。冷却,用玻璃棉去反应生成的少量焦油,滤渣用热水洗涤。过滤、洗液用乙醚提取,提取液经无水硫酸钠干燥后,蒸发回收乙醚,得粗品结晶。用真空升华可得7g纯白结晶成品。
  • Alfa Aesar:马来酰亚胺,98+% Maleimide, 98+%(541-59-3)
  • MSDS 信息:2,5-Pyrroledione(541-59-3).msds
  • 下游产品:N-(2-氨基乙基)马来酰亚胺 三氟乙酸盐 --> 4-马来酰亚胺丁酸 --> N-甲氧基羰基顺丁烯二酰亚胺
  • 海关编码:29251995
  • 图谱信息:马来酰亚胺(541-59-3)质谱(MS) 马来酰亚胺(541-59-3)核磁图( 13 CNMR) 马来酰亚胺(541-59-3)红外图谱(IR1) 马来酰亚胺(541-59-3)红外图谱(IR2) 马来酰亚胺(541-59-3)核磁图( 1 HNMR)

系列性分类


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