3-Chloropyridine 3-氯吡啶

CAS 626-60-8 MFCD00006375

化学结构图

626-60-8
SMILES: Clc1cccnc1

化学属性

Mol. FormulaC5H4ClN
Mol. Weight113.54
Density1.194
Refractive index1.5320 to 1.5340
Boiling Point148 °C at 760 mmHg
Flash Point66°C
TSCAYes
Melting Point135 °C

别名和识别编码

Chemical Name3-Chloropyridine
Synonym 3-Chloropyridine {LY} 3-Chloropyridine {} {LY} 3-Chloropyridine {} {} {LY} 3-Chloropyridine {} {} {} {LY} 3-Chloropyridine {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Chloropyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Ch
CAS Number626-60-8
EC Number210-955-7
Beilstein Registry Number105744
MDL NumberMFCD00006375
PubChem Substance ID12287
Reaxys-RN105744
Chemical Name Translation3-氯吡啶
Wiswesser Line NotationT6NJ CG
LabNetwork Molecule IDLN00011023
InChIInChI=1S/C5H4ClN/c6-5-2-1-3-7-4-5/h1-4H
Canonical SMILESClC1=CC=CN=C1
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分类

  • {SNA} Baran Sulfinate Building Block Collection, Building Blocks, C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines
  • {SNA} Building Blocks, C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines
  • {SNA} Baran Sulfinate Building Block Collection, Building Blocks, C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines, {Untitled Section}
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment

产品应用

  • 用作医药中间体。

相关文献及参考

  • Short: II/19c
  • With n-BuLi and TMEDA at -60 o, lithiation occurs predominantly at the 2-position, with some 4-lithiation: Tetrahedron, 39, 2009 (1983). With LDA at -60 o, exclusive 4-lithiation occurs: J. Org. Chem., 47, 2633 (1982); Heterocycles, 35, 151 (1993).
  • Short: II/19b
  • Short: II/14a
  • Beilstein:20(3/4)2497

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P312
  • P302+P350
  • P302+P352
  • P303+P361+P353
  • P304+P312
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H227 Combustible liquid 可燃液体
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUS6125000
Packing GroupIII
UN Number 2822 2924 UN 2822 UN2924
Hazard Codes 3
Hazard Class3
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
   Liver - fatty liver degeneration
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,361,1967

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1433 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1672 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1433 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,57,1993

其他信息

  • 3-氯吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0280 3-氯吡啶 3-Chloropyridine 500G 4150元 2014/06/02 C0280 3-氯吡啶 3-Chloropyridine 25G 497元 2010/06/21 110021000 3-氯吡啶 3-Chloropyridine 99% 100 ML 1485元
  • 下游产品:3-氨基-5-氯吡啶 --> 2,5-二氯吡啶 --> 5-硝基-3-氯吡啶 --> 3-氯-2-氰基吡啶 --> 3,4-二氯吡啶 --> 3-氯-4-吡啶硼酸(一水合物)
  • 用途一:用作医药中间体
  • Acros Organics:3-氯吡啶 3-Chloropyridine, 99%(626-60-8)
  • MSDS 信息:3-Pyridinyl chloride(626-60-8).msds
  • Sigma Aldrich:626-60-8(sigmaaldrich)
  • 图谱信息:3-氯吡啶(626-60-8)质谱(MS) 3-氯吡啶(626-60-8)核磁图( 1 HNMR) 3-氯吡啶(626-60-8)红外图谱(IR1) 3-氯吡啶(626-60-8)红外图谱(IR2)
  • TCI Shanghai:3-氯吡啶 3-Chloropyridine,>;95.0%(GC)(626-60-8)
  • Hazard Note:Harmful/Irritant
  • Alfa Aesar:3-氯吡啶,99% 3-Chloropyridine, 99%(626-60-8)
  • 海关编码:29333999
  • 水中溶解度: 10 g/L (20°C)
  • MOL 文件:626-60-8.mol

系列性分类


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