5-Chloro-8-hydroxyquinoline 5-氯-8-羟基喹啉

CAS 130-16-5 MFCD00006788

化学结构图

130-16-5
SMILES: Oc1ccc(Cl)c2cccnc12

化学属性

Mol. FormulaC9H6ClNO
Mol. Weight179.60
Melting Point122-124°C
Density1.422
TSCAYes
Solubility能溶于水、醇、醚和二硫化碳。
Boiling Point348.7±22.0 °C at 760 mmHg

别名和识别编码

Chemical Name5-Chloro-8-hydroxyquinoline
Synonym Cloxiquine {LY} Cloxiquine {} {LY} Cloxiquine {} {} {LY} Cloxiquine {} {} {} {LY} Cloxiquine {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cloxiquine {} {} {} {} {} {} {
MDL NumberMFCD00006788
PubChem Substance ID2817
Beilstein Registry Number5289
CAS Number130-16-5
EC Number204-978-1
Reaxys-RN5289
Merck Number2422
Chemical Name Translation5-氯-8-羟基喹啉
Wiswesser Line NotationT66 BNJ GG JQ
LabNetwork Molecule IDLN00195665
InChIInChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H
Canonical SMILESOC1=C2N=CC=CC2=C(Cl)C=C1
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分类

  • Building Blocks, C8 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinolines
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinolines

相关文献及参考

  • Merck: 14,2422
  • Merck: 14,2422 Beilstein:21,95

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSVC4590000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C Light Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 28,484,1931

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 307,141,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,335,1977

其他信息

  • 用途一:用于有机合成
  • 5-氯-8-羟基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0645 5-氯-8-羟基喹啉 5-Chloro-8-hydroxyquinoline 250G 967元 2014/06/02 C0645 5-氯-8-羟基喹啉 5-Chloro-8-hydroxyquinoline 25G 228元 2010/06/21 109305000 5-氯-8-羟基喹啉 5-Chloro-8-hydroxyquinoline 95% 500 GR 1699元
  • 方法一:以4-氯-2-氨基苯酚为原料,与丙烯醛发生Michael加成,经硝基酚脱氢制备5-氯-8-羟基喹啉【130-16-5】
  • 方法二:以8-羟基喹啉为原料,经不同的氯化剂进行多位氯化或选择性氯化生成5-氯-8-羟基喹啉【130-16-5】。
  • 上游原料:8-羟基喹啉
  • MOL 文件:130-16-5.mol
  • Sigma Aldrich:130-16-5(sigmaaldrich)
  • MSDS 信息:Cloxiquine(130-16-5).msds
  • 海关编码:29334990
  • TCI Shanghai:5-氯-8-羟基喹啉 5-Chloro-8-hydroxyquinoline,>;98.0%(GC)(T)(130-16-5)
  • Acros Organics:5-氯-8-羟基喹啉 5-Chloro-8-hydroxyquinoline, 95%(130-16-5)
  • 农药中间体:5-氯-8-羟基喹啉【130-16-5】是生产用于改良小麦、黑麦等对除草剂的耐药性，加速在作物植株中的解毒作用药物解毒喹的中间体。
  • 外观:白色或淡黄色结晶粉末，有特殊气味，有吸湿性。
  • Alfa Aesar:5-氯-8-羟基喹啉,95% 5-Chloro-8-hydroxyquinoline, 95%(130-16-5)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  5. C8 to C10 - Quinolines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Quinolines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Quinazolines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quinolines 喹啉

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