N-Cyanoguanidine 二氰二胺

CAS 461-58-5 MFCD00008066

化学结构图

461-58-5
SMILES: N#CN=C(N)N

化学属性

Mol. FormulaC2H4N4
Mol. Weight84.08
Melting Point208-211 °C
Density1.4
TSCAYes
SolubilitySoluble in Water: 0.1 g/mL
Stability对湿度敏感
Boiling Point144.35 °C at 760 mmHg

别名和识别编码

Chemical NameN-Cyanoguanidine
CAS Number461-58-5
Synonym Dicyandiamide {LY} Dicyandiamide {} {LY} Dicyandiamide {} {} {LY} Dicyandiamide {} {} {} {LY} Dicyandiamide {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dicyandiamide {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number605637
PubChem Substance ID10005
EC Number207-312-8
MDL NumberMFCD00008066
Reaxys-RN605637
Merck Number3092
Chemical Name Translation二氰二胺
LabNetwork Molecule IDLN00193332
Canonical SMILESNC(NC#N)=N
InChIInChI=1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)
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分类

  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Metformin hydrochloride Impurities, Pharmaceutical Impurities, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards,
  • {SNA} Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Metformin hydrochloride Impurities, Pharmaceutical Impurities, Pharmaceutical Standards, 分析/色谱
  • {SNA} Analytical Standards, Pharmacopeia Metrological Institutes S

产品应用

  • 检定钴、镍、铜和钯, 有机合成, 硝化纤维稳定剂, 硬化剂, 去垢剂, 硫化促进剂, 树脂合成。

相关文献及参考

  • Merck: 14,3092 Beilstein: 3,IV,160
  • Reacts with aromatic nitriles in the presence of base to give 6-aryl-1,3,5-triazines (benzoguanamines); see, e.g.: Org. Synth. Coll., 4, 78 (1963).
  • Short: II/27B
  • Merck: 14,3092
  • Kumar, U., et al.: Curr. Sci., 79, 224 (2000),
  • Di, H., et al.: Biol. Fertil. Soils, 2006, 42, 472 (2006),

安全信息

WGK Germany1
RTECSME9950000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
GHS Symbol
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P312
  • P304+P340
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes Xn
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   14,1325,1965

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,17,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   8,329,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   8,329,1952

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害

其他信息

  • MSDS 信息:氰基胍(461-58-5).msds
  • Alfa Aesar:氰基胍,99% Dicyandiamide, 99%(461-58-5)
  • 双氰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30056028 二氰二胺;氰胍; 双氰胺; 二聚氨基氰; 氰基胍
  • 用途三:是生产三聚氰胺的原料。也是医药和染料的中间体。在医药上用于制取硝酸胍、磺胺类药物等。也可用来制取硫脲、胍、硝酸纤维素稳定剂、橡胶硫化促进剂、钢铁表面硬化剂、印染固色剂、人造革填料及黏合剂等。
  • 防护措施:本品可能损伤皮肤，使用时应注意防止发生皮疹。
  • 方法二:把石灰氮（氰胺钙）与水进行水解，将所得的悬浮状水解液氰氨氢钙滤除去氢氧化钙，滤液通入二氧化碳脱钙，得到氰氨液。然后，使氰氨在弱
  • 常规方法:本品用编织袋内衬塑料袋包装，或用五层牛皮纸制成的纸袋包装。袋口应严封，不得泄漏，每袋净重25±
  • 常规方法:本品用编织袋内衬塑料袋包装，或用五层牛皮纸制成的纸袋包装。袋口应严封，不得泄漏，每袋净重25±0.2kg，每批每袋产品平均净重达25kg。应贮存于阴凉、干燥、通风处，切勿与氧化剂共贮存。在运输装卸中应防潮湿、轻拿轻放。
  • 上游原料:活性炭 --> 氢氧化钙 --> 碳酸钙 --> 氰氨化钙 --> 氰胺
  • Sigma Aldrich:461-58-5(sigmaaldrich)
  • 下游产品:3-(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)-1-(2-甲氧基甲酰基苯基)磺酰脲 --> 三聚氰胺 --> 氯磺隆 --> 硝酸胍 --> 苯磺隆 --> 2-氨基-4-甲基-6-甲氧基-1,3,5-三嗪 --> 2-甲基-4-甲胺基-6-甲氧基均三嗪 --> 伊索拉定 --> 甲嘧磺隆 --> 苯乙双胍 --> 脒基硫脲 --> 吗啉胍 --> 2,4-二氨基-6-苯基-1,3,5-三嗪 --> 固色剂M --> 玻璃纤维润滑剂G --> 固色剂Y --> 整理剂 FS --> 苯基-1,3,5-三嗪 --> 氨基磺酸胍 --> 树脂鞣剂RS --> 合成鞣剂MR102 --> 1,1-二甲基双胍盐酸盐 --> 二腈二胺甲醛缩合物 --> 盐酸苯乙福明
  • 用途一:是三聚氰胺的原料，也是合成医药、农药和染料的中间体
  • 用途四:双氰胺的主要用途有：（1）作为胍盐、三聚氰二胺类的原料。用双氰胺与酸反应，可制造各种胍盐。双氰胺和苯基腈反应得到的苯代三聚氰二胺是涂料，层压板、成型粉的中间体。（2）用作染料固色剂，双氰胺和甲醛反应制得的双氰胺树脂，可用作染料固色剂。（3）双氰胺化肥，双氰胺复合肥料可控制硝化菌的活动，使氮肥在土壤中的转化速度得到调节，减少氮的损失，提高肥料的使用效率。（4）作为精细化工中间体。在医药上用于制取硝酸胍、磺胺类药物等；也用来制取硫脲、硝酸纤维素稳定剂、橡胶硫化促进剂、钢铁表面硬化剂、人造革填料、粘合剂等。由双氰胺与甲酸反应可得医药中间体5-氮杂胞嘧啶。
  • 用途五:检定钴、镍、铜和钯, 有机合成, 硝化纤维稳定剂, 硬化剂, 去垢剂, 硫化促进剂, 树脂合成。
  • 图谱信息:双氰胺(461-58-5)质谱(MS) 双氰胺(461-58-5)红外图谱(IR1)
  • Acros Organics:二氰二胺 Dicyandiamide, 99.5%(461-58-5)
  • 水中溶解度在13℃时为2.26%，在热水中溶解度较大。当水溶液在80℃时逐渐分解产生氨，无水乙醇中溶解度在13℃时为1.2%，能溶于液氨，不溶于苯和氯仿。低毒，半数致死量(小鼠，经口)>4000mg/kg。
  • MOL 文件:461-58-5.mol
  • 用途二:用于有机合成和树脂合成，也用作硫化
  • 方法一:石灰氮法将石灰氮与水进行水解，反应所得悬浮状的氰氨氢钙水解液，经减压过滤除去氢氧化钙滤渣，将石灰石分解产生的二氧化碳通人滤液进行脱钙反应，生成氰氨液，在碱性条件下聚合，再经过滤、冷却结晶、分离、干燥，制得双氰胺。其 2CaCN2+2H2O→Ca(HCN2)2+Ca(OH)2 C

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Hydrazides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Hydrazides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Guanidines - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Impurities - Pharmaceutical Standards
  6. Metformin hydrochloride Impurities - Pharmaceutical Impurities
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Cyanides/Nitriles
  6. C8 to C9