N-Benzylidene-2-Methylpropan-2-Amine Oxide N-叔丁基-α-苯基硝酮

CAS 3376-24-7 MFCD00008799

化学结构图

3376-24-7
SMILES: CC(C)(C)/[N+]([O-])=C/c1ccccc1

化学属性

Mol. FormulaC11H15NO
Mol. Weight177
Melting Point73-77
TSCAYes
Density0.99
Solubility溶于DMSO (10 mg/ml), 氯仿 (50 mg/ml), 和水(20 mg/ml).
Appearance powder
Stability对空气敏感

别名和识别编码

Chemical NameN-Benzylidene-2-Methylpropan-2-Amine Oxide
Synonym PBN n-tert-butyl-alpha-phenyl-nitron N-tert-Butyl-α-phenylnitrone N-苯亚甲基-叔丁胺-N-氧化物 PBN 苯基·N-叔丁基硝酮 N-叔丁基-A-苯硝酮 N-TERT-BUTYL-A-PHENYLNITRONE 2-methyl-n-(phenylmethylene)-s-propanaminn-oxide N-T-BUTYL-ALPHA-PHENYLNITRONE PHENYL N-TERT-BUTYLNITRONE 2-phenyl-n-tert-butylnitrone N-叔丁基-а-苯基硝酮 2-methyl-n-(phenylmethylene)-s-propanaminen-oxide BENZYLIDENE(TERT-BUTYL)AMMONIUMOLATE 2-methyl-n-(phenylmethylene)-2-propanaminn-oxide n-tert-butyl-2-phenylnitrone n-tert-butyl-c-phenylnitrone N-TERT-BUTYL-ALPHA-PHENYLNITRONE Benzylidene(tert-butyl)azane oxide N-叔丁基-Α-苯基硝酸灵 N-叔丁基苯硝酮 N-叔丁基苯硝酮;N-苯亚甲基叔丁胺-N-氧化物;叔丁基(亚苄基)胺 N-氧化物;PBN benzylidene-tert-butylaminen-oxide N-叔丁基-#-苯基硝酮 N-苯亚甲基叔丁胺-N-氧化物 c-phenyl-n-tert-butylnitrone N-叔丁基苯硝酮;N-苯亚甲基叔丁胺-N-氧化物 N-BENZYLIDENE-TERT-BUTYLAMINE N-OXIDE n-benzylidene-tert-butylamineoxide N-叔丁基-α-苯基硝酮 N-叔丁基-Α-苯基硝酮 PBNalpha-Phenyl-N-tert-butylnitrone alpha-phenyl-n-tert-butylnitrone
Beilstein Registry Number1841513
CAS Number3376-24-7
EC Number222-168-6
MDL NumberMFCD00008799
Reaxys-RN1841513
PubChem Substance ID638877
Merck Number14,7056
Chemical Name TranslationN-叔丁基-α-苯基硝酮
InChIInChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
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分类

  • {SNA} A to C,
  • {SNA} A to C, Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cyclooxygenase, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates
  • Analytical Reagents,
  • {SNA} A to C, Application Index, Cell Signaling Enzymes, Cyclooxygenase, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, 生化试剂, 酶、抑制剂和底物
  • {SNA} Electron Spin Resonance (ESR/EPR) Spectroscopy, Spectroscopy, Spin Trapping Reagents, 分析/色谱, 分析试剂

产品应用

  • 一种Cox-2抑制剂。

相关文献及参考

  • [2]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57.
  • [3]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 19;1448(1):77-84.
  • [4]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec;222(3):236-45.
  • Floyd, R. A., Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system. Adv. Pharmacol. 38 , 361, (1997) 摘要
  • For examples of 1,3-dipolar cycloaddition reactions, see N,ɑ-Diphenyl­ nitrone, L00185.
  • Janzen, E.G., Biological spin trapping. II. Toxicity of nitrone spin traps: dose-ranging in the rat. J. Biochem. Biophys. Methods 30 , 239, (1995)
  • Merck 14 ,7056
  • Merck: 14,7056
  • Merck: 14,7056 Beilstein:7(

安全信息

RTECSTX1760000
WGK Germany3
Signal word Warning
GHS Symbol
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 储存温度：-20°C 储存温度 -20°C，充氩保存 2-8°C

其他信息

  • TCI Shanghai:N-叔丁基-α-苯基硝酮 N-tert-Butyl-alpha-phenylnitrone,>;98.0%(LC)(T)(3376-24-7)
  • 图谱信息:N-叔丁基-#-苯基硝酮(3376-24-7)核磁图( 13 CNMR) N-叔丁基-#-苯基硝酮(3376-24-7)质谱(MS) N-叔丁基-#-苯基硝酮(3376-24-7)红外图谱(IR2) N-叔丁基-#-苯基硝酮(3376-24-7)红外图谱(IR1) N-叔丁基-#-苯基硝酮(3376-24-7)Raman光谱 N-叔丁基-#-苯基硝酮(3376-24-7)核磁图( 1 HNMR)
  • F:10
  • 用途一:自旋捕集剂。
  • N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).
  • Alfa Aesar:N-叔丁基-α-苯基硝酮,98% N-tert-Butyl-alpha-phenylnitrone, 98%(3376-24-7)
  • 检测方法:HPLC
  • Sigma Aldrich:3376-24-7(sigmaaldrich)
  • MOL 文件:3376-24-7.mol
  • 下游产品:N-二甲氨基苄叔丁胺
  • Acros Organics:N-叔丁基-a-苯硝酮 N-tert-Butyl-alpha-phenylnitrone, 98%(3376-24-7)
  • N-叔丁基-#-苯基硝酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B1701 N-叔丁基-α-苯基硝酮 N-tert-Butyl-alpha-phenylnitrone 5G 1840元 2014/06/02 B1701 N-叔丁基-α-苯基硝酮 N-tert-Butyl-alpha-phenylnitrone 1G 629元 2010/06/21 177350050 N-叔丁基-#-苯基硝酮 N-tert-Butyl-alpha-phenylnitrone 98% 5 GR 1979元
  • N-叔丁基-#-苯基硝酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 B1701 N-叔丁基-α-苯基硝酮 N-tert-Butyl-alpha-phenylnitrone 5G 1840元 2011/04/16 B1701 N-叔丁基-α-苯基硝酮 N-tert-Butyl-alpha-phenylnitrone 1G 633元 2010/06/21 177350050 N-叔丁基-#-苯基硝酮 N-tert-Bu

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Oximes - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Spectroscopy - Analytical Reagents
  4. Electron Spin Resonance (ESR/EPR) Spectroscopy - Spectroscopy
  5. Spin Trapping Reagents - Electron Spin Resonance (ESR/EPR) Spectroscopy
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Cyclooxygenase (COX) Enzymes - Cell Signaling Enzymes
  7. Cyclooxygenase Inhibitors - Cyclooxygenase (COX) Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Cyclooxygenase (COX) Enzymes - Cell Signaling Enzymes
  7. Cyclooxygenase Inhibitors - Cyclooxygenase (COX) Enzymes
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Radical Chemistry - Synthetic Reagents
  4. Stable Radicals - Radical Chemistry
  5. Others - Stable Radicals
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Radical Chemistry - Synthetic Reagents
  4. Stable Radicals
  1. Analytical & Chromatography 分析化学与色谱
  2. ESR Spectrometry
  1. Functional Group 官能团索引
  2. N-oxide
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Cyclooxygenase (COX) Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Cyclin Dependent Kinases
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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