Pivalic anhydride 三甲基乙酸酐

CAS 1538-75-6 MFCD00008842

化学结构图

1538-75-6
SMILES: CC(C)(C)C(=O)OC(=O)C(C)(C)C

化学属性

Mol. FormulaC10H18O3
Mol. Weight186.25
Density0.918
Refractive index1.4070 to 1.4110
Flash Point57°C(lit.)
TSCAYes
Boiling Point193 °C at 760 mmHg

别名和识别编码

Chemical NamePivalic anhydride
CAS Number1538-75-6
Synonym Pivalic anhydride {LY} Pivalic anhydride {} {LY} Pivalic anhydride {} {} {LY} Pivalic anhydride {} {} {} {LY} Pivalic anhydride {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pivalic anhydride
MDL NumberMFCD00008842
EC Number216-263-1
Beilstein Registry Number386552
PubChem Substance ID15234
Reaxys-RN386552
Chemical Name Translation三甲基乙酸酐
InChIKeyPGZVFRAEAAXREB-UHFFFAOYSA-N
LabNetwork Molecule IDLN00223507
InChIInChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3
Canonical SMILESCC(C)(C)C(=O)OC(=O)C(C)(C)C
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分类

  • Pharmaceuticals
  • {uni_hamburg} no charge; carbo-anhydride; 1fragment
  • Intermediates & Fine Chemicals
  • {SNA} Building Blocks, Carbonyl Compounds, Carboxylic Acid Anhydrides, Chemical Synthesis, Organic Building Blocks
  • Aliphatics
  • Metabolites & Impurities

产品应用

  • A metabolite of a double prodrug (6-dGCV-DPiv

相关文献及参考

  • Krasny, H.C.
  • Short: EINECS
  • Alcohols can be protected as their pivaloyl (Pv) esters by reaction with the anhydride in the presence of MgBr2 - Et3N or Sc(OTf)3 in acetonitrile: J. Org. Chem., 61, 5702 (1996). See also Trimethyl­acetyl­ chloride, A15051.
  • The direct hydrogenation of carboxylic acids to aldehydes has been achieved in the presence of pivalic anhydride and Tetrakis(triphenyl­phosphine)­palladium(0)­, 10548: Chem. Lett., 1143 (1998).
  • Short: III/38B

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupII
UN Number 2920
Storage condition -20°C, sealed storage, away from moisture {LY} -20°C, sealed storage, away from moisture 2-8°C, sealed storage, away from moisture Moisture Sensitive Store at RT. {} {LY} -20°C, sealed storage, away from moisture {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 8 C
Hazard Class8/3

其他信息

  • MOL 文件:1538-75-6.mol
  • TCI Shanghai:2,2-二甲基丙酸酐 Pivalic Anhydride,>;98.0%(GC)(1538-75-6)
  • 三甲基乙酸酐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P1414 特戊酸酐 Pivalic Anhydride 25ML 486元 2014/06/02 P1414 特戊酸酐 Pivalic Anhydride 250ML 2550元 2010/06/21 162440500 三甲基乙酸酐 Trimethylacetic anhydride 99% 50 ML 1072元
  • Sigma Aldrich:1538-75-6(sigmaaldrich)
  • 图谱信息:三甲基乙酸酐(1538-75-6)质谱(MS) 三甲基乙酸酐(1538-75-6)红外图谱(IR1) 三甲基乙酸酐(1538-75-6)核磁图( 1 HNMR) 三甲基乙酸酐(1538-75-6)Raman光谱 三甲基乙酸酐(1538-75-6)核磁图( 13 CNMR)
  • Acros Organics:三甲基乙酸酐 Trimethylacetic anhydride, 99%(1538-75-6)
  • F:9-13-21
  • 敏感性:Moisture Sensitive
  • Alfa Aesar:三甲基乙酸酐,99% Trimethylacetic anhydride, 99%(1538-75-6)

系列性分类


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